National Institute of Cholera and Enteric Diseases, Beliaghata, Kolkata, India.
Infect Genet Evol. 2010 Mar;10(2):311-20. doi: 10.1016/j.meegid.2010.01.002. Epub 2010 Jan 18.
To determine the frequency and genotypes of rotavirus strains, samples were collected from children hospitalized with acute diarrhea at the Regional Institute of Medical Sciences, Manipur. The globally common genotypes G1P[8] and G2P[4] constituted 58% of the total positive strains, while 3% and 8% strains were emerging genotypes, G9P[6] and G12P[6]. This is the first report of genotype G12 in Manipur. The G12 strains clustered with lineage III strains and had >98% identity with corresponding rotaviruses from Bangladesh, Thailand and the USA. Other uncommon G-P combinations including G4P[4], G4P[6], G10P[6] and G9P[19], along with a few strains that could not be typed were also found. The VP7 genes of G4 and G10 strains clustered with porcine and bovine strains, indicating possible zoonotic transmission. High frequency (36-62%) of rotavirus infection and predominance of G1P[8] and G2P[4] among children with acute diarrhea emphasized the need for implementation of currently available vaccines to reduce the burden of rotavirus induced diarrhea in India.
为了确定轮状病毒株的频率和基因型，从曼尼普尔邦地区医学研究所因急性腹泻住院的儿童中采集了样本。全球常见的基因型 G1P[8]和 G2P[4]构成了总阳性株的 58%，而 3%和 8%的株为新兴基因型 G9P[6]和 G12P[6]。这是曼尼普尔邦首次报告基因型 G12。G12 株与谱系 III 株聚类，与来自孟加拉国、泰国和美国的相应轮状病毒具有 >98%的同一性。还发现了其他不常见的 G-P 组合，包括 G4P[4]、G4P[6]、G10P[6]和 G9P[19]，以及一些无法分型的毒株。G4 和 G10 株的 VP7 基因与猪和牛株聚类，表明可能存在人畜共患传播。轮状病毒感染的高频率（36-62%）和急性腹泻儿童中 G1P[8]和 G2P[4]的优势，强调需要实施现有的疫苗，以减轻印度轮状病毒引起的腹泻负担。
