钙离子诱导形成了两个不同的 II 组内含子分子亚群。
Ca2+ induces the formation of two distinct subpopulations of group II intron molecules.
机构信息
Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
出版信息
Angew Chem Int Ed Engl. 2009;48(51):9739-42. doi: 10.1002/anie.200903809.
Abstract
The folding pathway of the .ai5γ derived group II intron ribozyme D135 is highly specific to the correct M cofactor. Upon partial replacement of Mg with Ca, the molecules split into two distinct static subpopulations that are not interchangeable. Type 2 molecules thereby form a compact but misfolded state.
摘要
.D135 衍生的 II 类内含子核酶的折叠途径对正确的 M 辅因子具有高度特异性。用 Ca 部分取代 Mg 后，分子分裂成两个不同的静态亚群，它们不能互换。因此，2 型分子形成紧凑但错误折叠的状态。
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