Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
Angew Chem Int Ed Engl. 2009;48(51):9739-42. doi: 10.1002/anie.200903809.
The folding pathway of the .ai5γ derived group II intron ribozyme D135 is highly specific to the correct M cofactor. Upon partial replacement of Mg with Ca, the molecules split into two distinct static subpopulations that are not interchangeable. Type 2 molecules thereby form a compact but misfolded state.
.D135 衍生的 II 类内含子核酶的折叠途径对正确的 M 辅因子具有高度特异性。用 Ca 部分取代 Mg 后，分子分裂成两个不同的静态亚群，它们不能互换。因此，2 型分子形成紧凑但错误折叠的状态。
