基因平衡假说：对基因调控、数量性状和进化的影响。
The gene balance hypothesis: implications for gene regulation, quantitative traits and evolution.
机构信息
Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA.
出版信息
New Phytol. 2010 Apr;186(1):54-62. doi: 10.1111/j.1469-8137.2009.03087.x. Epub 2009 Nov 19.
Abstract
The gene balance hypothesis states that the stoichiometry of members of multisubunit complexes affects the function of the whole because of the kinetics and mode of assembly. Gene regulatory mechanisms also would be governed by these principles. Here, we review the impact of this concept with regard to the effects on the genetics of quantitative traits, the fate of duplication of genes following polyploidization events or segmental duplication, the basis of aneuploid syndromes, the constraints on cis and trans variation in gene regulation and the potential involvement in hybrid incompatibilities.
摘要
基因平衡假说指出，由于动力学和组装方式的原因，多亚基复合物成员的化学计量会影响整个复合物的功能。基因调控机制也将受到这些原则的制约。在这里，我们回顾了这一概念对数量性状遗传、多倍体事件或片段重复后基因复制的命运、非整倍体综合征的基础、基因调控中顺式和反式变异的限制以及杂种不育性潜在涉及等方面的影响。
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