Alonso-Blanco Carlos, Méndez-Vigo Belén
Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Darwin 3, Madrid 28049, Spain.
Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Darwin 3, Madrid 28049, Spain.
Curr Opin Plant Biol. 2014 Apr;18:37-43. doi: 10.1016/j.pbi.2014.01.002. Epub 2014 Feb 21.
Deciphering the genetic and molecular bases of quantitative variation is a long-standing challenge in plant biology because it is essential for understanding evolution and for accelerating plant breeding. Recent multi-trait analyses at different phenotypic levels are uncovering the pleiotropy and the genetic regulation underlying high-level complex traits. Thus, the number of known causal loci, genes and nucleotide polymorphisms is expanding. Current plant causal catalogs contain ∼400 genes and natural polymorphisms revealing several dysfunctional allelic series that involve multiple mutations. In addition, repeated evolution of quantitative traits mediated by large effect alleles is found across plant phylogeny. Finally, systematic analyses of genetic and environmental interactions are beginning to elucidate the molecular mechanisms of relevant interactions.
解析数量变异的遗传和分子基础是植物生物学中一个长期存在的挑战，因为这对于理解进化和加速植物育种至关重要。最近在不同表型水平上进行的多性状分析正在揭示高水平复杂性状背后的多效性和遗传调控。因此，已知的因果位点、基因和核苷酸多态性的数量正在不断增加。目前的植物因果目录包含约400个基因和自然多态性，揭示了几个涉及多个突变的功能失调等位基因系列。此外，在整个植物系统发育过程中都发现了由大效应等位基因介导的数量性状的重复进化。最后，对遗传和环境相互作用的系统分析开始阐明相关相互作用的分子机制。
