Laquer Vivian, Hoang Van, Nguyen Amy, Kelly Kristen M
Columbia University College of Physicians, New York, New York, USA.
J Am Acad Dermatol. 2009 Dec;61(6):945-58; quiz 959-60. doi: 10.1016/j.jaad.2009.05.053.
This review will discuss the role of angiogenesis in specific cutaneous diseases. Scientific evidence now points to the role of angiogenesis in tumor development and many other cutaneous disorders. Angiogenesis is a complex process that involves angiogenic growth factors and inhibitors, many of which could be a potential target for pharmacologic intervention. Antiangiogenic agents have recently been applied to dermatologic diseases with promising efficacy.
After completing this learning activity, participants should be able to recognize cutaneous diseases where angiogenesis is likely to be an important factor, recognize scenarios where angiogenic therapy may be useful in conjunction with traditional therapies, and be able to use angiogenic-mediating agents in the treatment of dermatologic disease.
本综述将探讨血管生成在特定皮肤疾病中的作用。目前科学证据表明血管生成在肿瘤发展及许多其他皮肤疾病中发挥作用。血管生成是一个复杂的过程,涉及血管生成生长因子和抑制剂,其中许多可能成为药物干预的潜在靶点。抗血管生成药物最近已应用于皮肤病治疗,疗效令人期待。
完成本学习活动后,参与者应能够识别血管生成可能是重要因素的皮肤疾病,识别血管生成疗法与传统疗法联合使用可能有效的情况,并能够在皮肤病治疗中使用血管生成介导剂。