Global burden and epidemiology of tuberculosis.

Tuberculosis (TB) ranks second only to human immunodeficiency virus as a cause of death from an infectious agent (1.77 million deaths from TB in 2007). Global targets for reductions in the epidemiologic burden of TB have been set for 2015 and 2050 within the context of the Millennium Development Goals and the Stop TB Partnership. Achieving these targets is the focus of national and international efforts in TB control, and demonstrating whether or not they are achieved is of major importance. This article discusses: the methods used by the World Health Organization to estimate the global burden of TB; estimates of incidence, prevalence, and mortality for 2007, combined with assessment of progress toward the 2015 targets for reductions in these indicators based on trends since 1990 and projections up to 2015; trends in TB notifications and case detection rates; and prospects for elimination of TB by 2050.