Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Vet Microbiol. 2010 May 19;142(3-4):416-9. doi: 10.1016/j.vetmic.2009.10.014. Epub 2009 Oct 28.
Adenovirus (AdV) has been recently detected among monkeys with diarrhea in a major research primate colony in China. To better assess disease burden and epidemiology of adenoviruses in the colony, we examined the prevalence of this virus in fecal specimens by PCR using broadly reactive hexon gene-specific primers. Of the 29 strains that were characterized by sequence and phylogenetic analysis, we identified a broad spectrum of simian AdV (SAdV) types, including species SAdV-A (n=14) and HAdV-G (n=9). Six additional strains represented two genetic clusters distantly related to other known SAdVs. A better understanding of the epidemiology of SAdVs and their potential role in gastroenteritis is critical to the implementation of advanced prevention strategies against AdV infection in captive primates.
腺病毒（AdV）最近在中国一个主要的灵长类动物研究繁殖地的腹泻猴子中被检测到。为了更好地评估该病毒在繁殖地的疾病负担和流行病学，我们使用广泛反应的六邻体基因特异性引物通过 PCR 检查粪便样本中该病毒的流行率。通过序列和系统发育分析对 29 株进行了鉴定，我们确定了广泛的猴腺病毒（SAdV）类型，包括 SAdV-A 种（n=14）和 HAdV-G 种（n=9）。另外 6 株代表与其他已知 SAdV 关系较远的两个遗传簇。更好地了解 SAdV 的流行病学及其在胃肠炎中的潜在作用，对于实施针对圈养灵长类动物 AdV 感染的先进预防策略至关重要。
