Rinfret A, Latendresse H, Lefebvre R, St-Louis G, Jolicoeur P, Lamarre L
Laboratory of Molecular Biology, Hôtel-Dieu de Montréal, Québec, Canada.
Am J Pathol. 1991 Feb;138(2):421-6.
Human immunodeficiency virus (HIV)-infected multinucleated giant cells previously were detected only in the central nervous system of HIV-positive patients. Reported here are the first cases in which such infected cells were observed outside the central nervous system, in the oropharyngeal lymphoid tissues. Tonsils and adenoids were removed individually from two asymptomatic homosexual men. Follicular hyperplasia and many interfollicular multinucleated giant cells most often in contact with or in close proximity of the mucous membrane were seen. The latter were positive for lysozyme, alpha-1 anti-chymotrypsin, OKM1, and S-100 protein in accordance with a histiocytic origin. In situ hybridization with an HIV envelope-specific RNA probe demonstrated the presence of viral RNA in these multinucleated giant cells. These findings support the role of peripheral histiocytes as a primary virus reservoir early in the disease. They also underline the potential role of oropharyngeal tissue as a primary target in some cases.
人类免疫缺陷病毒（HIV）感染的多核巨细胞以前仅在HIV阳性患者的中枢神经系统中被检测到。本文报道了首例在中枢神经系统外的口咽淋巴组织中观察到此类感染细胞的病例。从两名无症状的同性恋男性身上分别切除了扁桃体和腺样体。可见滤泡增生以及许多通常与黏膜接触或紧邻黏膜的滤泡间多核巨细胞。根据组织细胞起源，后者对溶菌酶、α-1抗糜蛋白酶、OKM1和S-100蛋白呈阳性反应。用HIV包膜特异性RNA探针进行原位杂交显示这些多核巨细胞中存在病毒RNA。这些发现支持外周组织细胞在疾病早期作为主要病毒储存库的作用。它们还强调了口咽组织在某些情况下作为主要靶标的潜在作用。
