Boethius G, Westerholm B
Acta Psychiatr Scand. 1977 Aug;56(2):147-59. doi: 10.1111/j.1600-0447.1977.tb06673.x.
Data from a continuous recording of drug prescriptions to 16,600 individuals in the county of Jämtland, Sweden, revealed that 2,566 patients (15.5%) obtained prescriptions for hypnotics, sedatives and minor tranquillizers in 1970. Occasional use (one purchase only, Group A) was seen in 7.4% of the population, intermediate use (two to six purchases, Group B) in 6.9% whereas 1.2% were regular users (seven purchases or more, Group C). For each group as a whole there was 5 years later a highly significant intraindividual reduction in the purchases of these drugs as well as of other psychotropic drugs. In all groups 10-23% had increased their purchases, most of them insignificantly. Fifteen of 30 patients with a marked increase in consumption developed a regular purchase pattern, but signs of overuse or abuse were seen in only four persons. During the studied period the benzodiazepines increased their share of the total from 45 to 60%. Antihistamines also increased in all groups while the proportion of barbiturates and combined preparations decreased markedly.
对瑞典耶姆特兰郡16600人的药物处方进行连续记录的数据显示,1970年有2566名患者(15.5%)开具了催眠药、镇静剂和轻度安定药的处方。偶尔使用(仅购买一次,A组)的情况在7.4%的人群中出现,中度使用(购买两至六次,B组)的情况在6.9%的人群中出现,而1.2%为经常使用者(购买七次或更多次,C组)。对于每个总体组而言,五年后这些药物以及其他精神药物的个体购买量均出现了高度显著的减少。在所有组中,10%至23%的人增加了购买量,其中大多数增幅不显著。30名消费显著增加的患者中有15人形成了规律的购买模式,但仅4人出现了过度使用或滥用的迹象。在研究期间,苯二氮䓬类药物在总量中的占比从45%增至60%。所有组中抗组胺药的使用量也有所增加,而巴比妥类药物和复方制剂的比例则显著下降。