Robbins S H, Conly M A, Oettinger J
Department of Pathology, Anne Arundel Medical Center, Annapolis, Md.
Arch Pathol Lab Med. 1991 Feb;115(2):155-7.
Transient cold agglutination of her granulocytes developed in a 60-year-old woman with a left upper lobe pneumonia during the acute phase of her illness. This phenomenon was manifested by pseudogranulocytopenia, multiple clumps of granulocytes on her peripheral blood smear, and abnormal distribution of granulocytes and monocytes on the white blood cell histogram when measured on an automated hematology analyzer (Coulter S-Plus IV, Coulter Electronics Inc, Hialeah, Fla). The cause is postulated to be an IgM autoantibody directed against components of the granulocyte membranes. Spurious leukopenia is encountered infrequently with automated hematology analyzers. Cold-induced granulocyte agglutination should be recognized as a potential cause of pseudogranulocytopenia so that white blood cell counts can be accurately reported and unnecessary evaluation of patients for leukopenia can be avoided.
一名60岁患有左上叶肺炎的女性在疾病急性期出现了粒细胞短暂冷凝集现象。这种现象表现为假性粒细胞减少、外周血涂片上有多个粒细胞团块，以及在自动血液分析仪（库尔特S-Plus IV，库尔特电子公司，佛罗里达州海厄利亚）上检测时白细胞直方图上粒细胞和单核细胞分布异常。推测其病因是一种针对粒细胞膜成分的IgM自身抗体。自动血液分析仪很少出现假性白细胞减少。冷诱导的粒细胞凝集应被视为假性粒细胞减少的潜在原因，以便能够准确报告白细胞计数，并避免对白细胞减少患者进行不必要的评估。
