Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Liver Int. 2010 Feb;30(2):268-74. doi: 10.1111/j.1478-3231.2009.02172.x. Epub 2009 Nov 19.
To identify the normal range of liver stiffness (LS) values by recruiting healthy living liver and kidney donors in South Korea.
Liver stiffness measurement (LSM) was performed in 69 healthy living liver and kidney donors who were admitted for transplantation. None of the subjects suffered from diabetes mellitus, hypertension, hepatitis B virus infection, hepatitis C virus infection, heart dysfunction, liver dysfunction or metabolic syndrome.
LSM failure rate was 2.7%. Among 12 liver donors (17.4%) with available liver histology, eight showed normal liver histology and four showed liver steatosis of <5% of the hepatocytes. The mean age of our study population was 38.9+/-11.9 years (35 men and 34 women), with a mean LS value of 4.6+/-0.5 kPa (range 3.3-5.6 kPa). LS values were not significantly different between men (4.6+/-0.6 kPa) and women (4.5+/-0.5 kPa, P=0.636), nor were they significantly different according to age (P=0.851). Using the fifth and 95th percentiles, we determined the normal range of LS values to be 3.9-5.3 kPa.
We identified the normal range of LS values and found that LS values were not significantly influenced by age and gender.
通过招募韩国健康的活体肝和肾供体，确定肝脏硬度（LS）的正常值范围。
对 69 名接受移植的健康活体肝和肾供体进行了肝脏硬度测量（LSM）。所有受试者均未患有糖尿病、高血压、乙型肝炎病毒感染、丙型肝炎病毒感染、心功能障碍、肝功能障碍或代谢综合征。
LSM 失败率为 2.7%。在 12 名有肝组织学检查结果的肝供体（17.4%）中，8 名显示正常肝组织学，4 名显示肝细胞脂肪变性<5%。本研究人群的平均年龄为 38.9+/-11.9 岁（35 名男性和 34 名女性），平均 LS 值为 4.6+/-0.5 kPa（范围 3.3-5.6 kPa）。男性（4.6+/-0.6 kPa）和女性（4.5+/-0.5 kPa，P=0.636）的 LS 值无显著差异，且与年龄也无显著差异（P=0.851）。使用第 5 百分位数和第 95 百分位数，我们确定 LS 值的正常范围为 3.9-5.3 kPa。
我们确定了 LS 值的正常范围，并发现 LS 值不受年龄和性别显著影响。
