Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
J Gastroenterol Hepatol. 2012 Jan;27(1):130-6. doi: 10.1111/j.1440-1746.2011.06814.x.
Although several studies have investigated the normal range of liver elasticity using acoustic radiation force impulse (ARFI) elastography in healthy volunteers, they could not strictly exclude the morphological and functional liver abnormalities. The aim of this study was to identify the normal range of ARFI velocity by recruiting healthy living liver and kidney donors who passed the full laboratory tests and imaging studies.
The study prospectively enrolled 108 healthy living liver (n = 42) and kidney donors (n = 66) who were admitted for transplantation between July 2010 to April 2011. None of the subjects had abnormal liver function test and imaging findings including conventional ultrasonography, computed tomography or magnetic resonance imaging.
The mean age of the study population (58 men and 50 women) was 35.5 years, and the mean ARFI velocity was 1.07 ± 0.11 m/s (range: 0.79-1.27). ARFI velocity was not significantly different between subjects with body mass index (BMI) < 23.5 kg/m(2) and those with BMI ≥ 23.5 kg/m(2) (1.05 ± 0.12 m/s vs 1.07 ± 0.10 m/s, P = 0.518), nor was it significantly different according to age (P = 0.067) and gender (1.08 ± 0.12 m/s for men vs 1.05 ± 0.11 m/s for women, P = 0.085). Using the 5(th) and 95(th) percentiles, we determined the normal range and mean of ARFI velocity to be 0.85-1.25 m/s and 1.07 ± 0.11 m/s.
We identified the normal range of ARFI velocity as 0.85-1.25 m/s and found that it was not significantly influenced by BMI, gender, and age.
虽然已有几项研究利用声辐射力脉冲（ARFI）弹性成像技术在健康志愿者中调查了肝脏弹性的正常范围，但这些研究无法严格排除肝脏形态和功能异常。本研究的目的是通过招募通过全面实验室检查和影像学研究的健康活体肝和肾供者来确定 ARFI 速度的正常范围。
该研究前瞻性纳入了 2010 年 7 月至 2011 年 4 月期间因移植而入院的 108 例健康活体肝（n=42）和肾供者（n=66）。所有受试者的肝功能检查和影像学表现均无异常，包括常规超声、计算机断层扫描或磁共振成像。
研究人群（58 名男性和 50 名女性）的平均年龄为 35.5 岁，平均 ARFI 速度为 1.07±0.11m/s（范围：0.79-1.27）。BMI＜23.5kg/m²和 BMI≥23.5kg/m²的受试者之间的 ARFI 速度无显著差异（1.05±0.12m/s vs. 1.07±0.10m/s，P=0.518），年龄（P=0.067）和性别（男性 1.08±0.12m/s 与女性 1.05±0.11m/s，P=0.085）也无显著差异。使用第 5 和 95 百分位数，我们确定 ARFI 速度的正常范围和平均值为 0.85-1.25m/s 和 1.07±0.11m/s。
我们确定了 ARFI 速度的正常范围为 0.85-1.25m/s，并发现其不受 BMI、性别和年龄的显著影响。
