Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Nucleic Acids Res. 2010 Jan;38(Database issue):D600-6. doi: 10.1093/nar/gkp1046. Epub 2009 Nov 20.
MouseIndelDB is an integrated database resource containing thousands of previously unreported mouse genomic indel (insertion and deletion) polymorphisms ranging from approximately 100 nt to 10 Kb in size. The database currently includes polymorphisms identified from our alignment of 26 million whole-genome shotgun sequence traces from four laboratory mouse strains mapped against the reference C57BL/6J genome using GMAP. They can be queried on a local level by chromosomal coordinates, nearby gene names or other genomic feature identifiers, or in bulk format using categories including mouse strain(s), class of polymorphism(s) and chromosome number. The results of such queries are presented either as a custom track on the UCSC mouse genome browser or in tabular format. We anticipate that the MouseIndelDB database will be widely useful for research in mammalian genetics, genomics, and evolutionary biology. Access to the MouseIndelDB database is freely available at: http://variation.osu.edu/.
MouseIndelDB 是一个综合性数据库资源，包含数千种以前未报道的小鼠基因组插入缺失（insertion and deletion）多态性，大小从大约 100 nt 到 10 Kb 不等。该数据库目前包含了我们通过 GMAP 将来自四个实验室小鼠品系的 2600 万条全基因组鸟枪法序列轨迹与参考 C57BL/6J 基因组进行比对后，在局部水平上根据染色体坐标、附近基因名称或其他基因组特征标识符识别出的多态性。也可以使用包括小鼠品系、多态性类别和染色体数量等类别以批量格式进行查询。此类查询的结果可以在 UCSC 小鼠基因组浏览器上作为自定义轨迹呈现，也可以以表格形式呈现。我们预计 MouseIndelDB 数据库将广泛应用于哺乳动物遗传学、基因组学和进化生物学的研究。MouseIndelDB 数据库的访问网址为：http://variation.osu.edu/。
