与 HLA-B*5701 相关的 HCP5 基因多态性不会限制 HIV-1 的体外复制。
A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro.
机构信息
Center for Human Genome Variation, Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA.
出版信息
AIDS. 2010 Jan 2;24(1):155-7. doi: 10.1097/QAD.0b013e32833202f5.
Abstract
A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. No significant HIV-1 restriction was observed in the cells with infectivity assays throughout HIV-1 life cycle, suggesting that the association of HCP5 variant with viral control is likely due to HLA-B5701-related effect or other functional variants in the haplotype or both.
摘要
单核苷酸多态性（rs2395029）位于 HCP5 基因中，与 HLA-B5701 相关，与 HIV-1 病毒设定点较低相关。编码区的两种等位基因形式在 TZM-bl 细胞中异位表达，对 HIV-1 复制产生影响。通过整个 HIV-1 生命周期的感染性测定，在细胞中未观察到明显的 HIV-1 限制，表明 HCP5 变体与病毒控制的关联可能是由于 HLA-B5701 相关效应或单体型中的其他功能变体或两者共同作用所致。
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本文引用的文献
1
Host genetics and HIV-1 viral load set-point in African-Americans.非裔美国人中的宿主遗传学和 HIV-1 病毒载量设定点。
AIDS. 2009 Mar 27;23(6):673-7. doi: 10.1097/QAD.0b013e328325d414.
2
Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).一项艾滋病非进展队列的全基因组关联研究强调了HLA基因所起的作用（ANRS全基因组关联研究02）。
J Infect Dis. 2009 Feb 1;199(3):419-26. doi: 10.1086/596067.
3
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AIDS. 2009 Jan 2;23(1):19-28. doi: 10.1097/QAD.0b013e32831db247.
4
Measuring HIV neutralization in a luciferase reporter gene assay.在荧光素酶报告基因检测中测量HIV中和作用。
Methods Mol Biol. 2009;485:395-405. doi: 10.1007/978-1-59745-170-3_26.
5
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6
T cell responses to human endogenous retroviruses in HIV-1 infection.HIV-1感染中T细胞对人类内源性逆转录病毒的反应。
PLoS Pathog. 2007 Nov;3(11):e165. doi: 10.1371/journal.ppat.0030165.
7
A whole-genome association study of major determinants for host control of HIV-1.一项关于宿主对HIV-1控制的主要决定因素的全基因组关联研究。
Science. 2007 Aug 17;317(5840):944-7. doi: 10.1126/science.1143767. Epub 2007 Jul 19.
8
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC.用于扩展人类主要组织相容性复合体疾病关联研究的高分辨率HLA和单核苷酸多态性单倍型图谱。
Nat Genet. 2006 Oct;38(10):1166-72. doi: 10.1038/ng1885. Epub 2006 Sep 24.
9
The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys.细胞质体成分TRIM5α限制旧世界猴中的HIV-1感染。
Nature. 2004 Feb 26;427(6977):848-53. doi: 10.1038/nature02343.
10
Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection.HLA - B57对急性HIV - 1感染期间临床表现及病毒控制的影响
AIDS. 2003 Dec 5;17(18):2581-91. doi: 10.1097/00002030-200312050-00005.
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