Center for Human Genome Variation, Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA.
AIDS. 2010 Jan 2;24(1):155-7. doi: 10.1097/QAD.0b013e32833202f5.
A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. No significant HIV-1 restriction was observed in the cells with infectivity assays throughout HIV-1 life cycle, suggesting that the association of HCP5 variant with viral control is likely due to HLA-B5701-related effect or other functional variants in the haplotype or both.
单核苷酸多态性（rs2395029）位于 HCP5 基因中，与 HLA-B5701 相关，与 HIV-1 病毒设定点较低相关。编码区的两种等位基因形式在 TZM-bl 细胞中异位表达，对 HIV-1 复制产生影响。通过整个 HIV-1 生命周期的感染性测定，在细胞中未观察到明显的 HIV-1 限制，表明 HCP5 变体与病毒控制的关联可能是由于 HLA-B5701 相关效应或单体型中的其他功能变体或两者共同作用所致。
