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Use of microRNA sponges to explore tissue-specific microRNA functions in vivo.

作者信息

Cohen Stephen M

机构信息

Department of Biological Sciences, National University of Singapore, Singapore.

出版信息

Nat Methods. 2009 Dec;6(12):873-4. doi: 10.1038/nmeth1209-873.

DOI:10.1038/nmeth1209-873
PMID:19935840
Abstract

MicroRNA depletion by sequestration produces flexible hypomorphs that mimic mutants obtained by microRNA gene targeting.

摘要

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2
Recombinase-mediated cassette exchange provides a versatile platform for gene targeting: knockout of miR-31b.重组酶介导的盒式交换为基因靶向提供了一个通用的平台：miR-31b 的敲除。
Genetics. 2009 Sep;183(1):399-402. doi: 10.1534/genetics.109.105213. Epub 2009 Jun 29.
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An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice.
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Front Oncol. 2020 Apr 15;10:370. doi: 10.3389/fonc.2020.00370. eCollection 2020.
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Gene regulatory network architecture in different developmental contexts influences the genetic basis of morphological evolution.不同发育背景下的基因调控网络结构影响形态进化的遗传基础。
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