Department of Medicine, University of Maryland School of Medicine, 20 Penn Street, HSF-II, Room S-114, Baltimore, MD 21201, USA.
Arch Virol. 2010;155(1):83-7. doi: 10.1007/s00705-009-0549-8. Epub 2009 Nov 20.
Genome sequences of human rhinoviruses (HRV) have primarily been from stocks collected in the 1960s, with genomes and phylogeny of modern HRVs remaining undefined. Here, two modern isolates (hrv-A101 and hrv-A101-v1) collected approximately 8 years apart were sequenced in their entirety. Incorporation into our full-genome HRV alignment with subsequent phylogenetic network inference indicated that these represent a unique HRV-A, localized within a distinct divergent clade. They appear to have resulted from recombination of the hrv-65 and hrv-78 lineages. These results support our contention that there are unrecognized distinct HRV-A strains, and that recombination is evident in currently circulating strains.
人类鼻病毒（HRV）的基因组序列主要来自 20 世纪 60 年代采集的病毒株，而现代 HRV 的基因组和系统发育仍然尚未明确。在这里，我们对大约相隔 8 年收集的两个现代分离株（hrv-A101 和 hrv-A101-v1）进行了全基因组测序。将它们整合到我们的全基因组 HRV 序列比对中，并进行随后的系统发育网络推断，表明它们代表了一个独特的 HRV-A 株，位于一个独特的分支中。它们似乎是由 hrv-65 和 hrv-78 两个谱系重组而来。这些结果支持我们的观点，即存在未被识别的独特 HRV-A 株，重组在当前流行的株系中很明显。
