在 C-H 键活化中释放应变？
Strain release in C-H bond activation?
机构信息
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
Angew Chem Int Ed Engl. 2009;48(51):9705-8. doi: 10.1002/anie.200904474.
Abstract
[Image: see text] In 1955 the principle of strain release was put forward to explain the differing reactivity of axial and equitorial alcohols during oxidation. Our findings suggest that this same rationale may account for the differing rates of activation between axial and equitorial C–H bonds in C–H activation processes. In conjunction with steric and electronic considerations, strain-release can be used to qualitatively predict relative rates and site specificity of C–H activation in complex settings.
摘要
[图像：见正文] 1955 年，人们提出应变释放原理来解释在氧化过程中轴向和赤道醇的不同反应性。我们的研究结果表明，这一原理同样可以解释在 C-H 键活化过程中轴向和赤道 C-H 键的活化速率不同。应变释放可与空间和电子因素结合使用，定性预测在复杂环境中 C-H 键活化的相对速率和位点特异性。
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