Department of Ophthalmology, Chunchon Sacred Heart Hospital, Hallym University, Chunchon, Republic of Korea.
Ophthalmologica. 2010;224(4):224-9. doi: 10.1159/000260228. Epub 2009 Nov 24.
To investigate the clinical features of pegylated-interferon (PEG-IFN)-associated retinopathy in chronic hepatitis patients.
We examined a consecutive case series of 46 patients who were treated with PEG-IFN for chronic hepatitis C or B between October 2007 and September 2008. All patients underwent regular ophthalmologic examinations every 3 weeks during the 6 months after treatment.
Ten of the 46 patients (21.73%) developed retinal abnormalities. PEG-IFN-associated retinopathy occurred a mean of 7.25 +/- 10.28 weeks after treatment and manifested itself as cotton wool spots and retinal hemorrhages. All patients, except for 1 with a retinal vein occlusion, recovered without cessation of treatment.
PEG-IFN-associated retinopathy in chronic hepatitis patients was reversible, and patients recovered without visual complications; however, 1 patient did present with an irreversible visual impairment. This type of retinopathy is usually asymptomatic, and clinicians should closely observe patients for 3 months after treatment.
研究聚乙二醇干扰素（PEG-IFN）相关的慢性肝炎患者的视网膜病变的临床特征。
我们检查了 46 例连续病例，这些患者于 2007 年 10 月至 2008 年 9 月期间接受 PEG-IFN 治疗慢性丙型或乙型肝炎。所有患者在治疗后 6 个月内每 3 周接受一次常规眼科检查。
46 例患者中有 10 例（21.73％）出现视网膜异常。PEG-IFN 相关的视网膜病变发生在治疗后平均 7.25 +/- 10.28 周，表现为棉絮斑和视网膜出血。除 1 例视网膜静脉阻塞外，所有患者均未停止治疗而恢复。
慢性肝炎患者的 PEG-IFN 相关的视网膜病变是可逆的，患者恢复后没有视觉并发症；然而，1 例患者确实出现了不可逆转的视力损害。这种类型的视网膜病变通常无症状，临床医生应在治疗后密切观察患者 3 个月。
