Ghosal Nandita, Furtado Sunil V, Hegde A S
Department of Pathology and Transfusion Medicine, Sri Sathya Sai Institute of Higher Medical Sciences (SSSIHMS), Bangalore, Karnataka, India.
Diagn Cytopathol. 2010 Aug;38(8):590-3. doi: 10.1002/dc.21269.
We present an extremely rare case of newly described entity called rosette forming glioneuronal tumor (RGNT), involving the pineal gland, tectum, and the adjacent thalamus in a 22-year-old male. Interestingly, the ventricular system was not involved in this case. The tumor was diagnosed intraoperatively on smear preparation on cytomorphology. If sampled adequately, it is fairly easy to diagnose RGNT on smear preparation as it has a very distinctive cytomorphology of being composed of two population of cell. One of the components is pilocytic astrocytoma and the other is composed of small cells with scant cytoplasm, vesicular nuclei, arranged around neuropil-like material forming "neurocytic rosettes." To the best of our knowledge, this is the first case of RGNT in this rare location being diagnosed intraoperatively on smear preparation.
我们报告了一例极为罕见的新描述实体——菊形团形成性胶质神经元肿瘤(RGNT),该肿瘤累及一名22岁男性的松果体、顶盖及相邻丘脑。有趣的是,本例未累及脑室系统。肿瘤在术中通过细胞涂片形态学检查得以诊断。如果取材充分,在涂片上诊断RGNT相当容易,因为它具有非常独特的细胞形态学特征,由两种细胞群组成。其中一种成分是毛细胞型星形细胞瘤,另一种由细胞质稀少、核呈空泡状的小细胞组成,这些小细胞围绕神经毡样物质排列形成“神经细胞菊形团”。据我们所知,这是首例在该罕见部位通过术中涂片诊断的RGNT病例。