Buratowski Stephen
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Mol Cell. 2009 Nov 25;36(4):541-6. doi: 10.1016/j.molcel.2009.10.019.
The C-terminal domain of RNA polymerase II's largest subunit undergoes dynamic phosphorylation during transcription, and the different phosphorylation patterns that predominate at each stage of transcription recruit the appropriate set of mRNA-processing and histone-modifying factors. Recent papers help to explain how the changes in CTD phosphorylation pattern are linked to the progression from initiation through elongation to termination.
RNA聚合酶II最大亚基的C末端结构域在转录过程中经历动态磷酸化，并且在转录每个阶段占主导的不同磷酸化模式会招募合适的一组mRNA加工和组蛋白修饰因子。最近的论文有助于解释CTD磷酸化模式的变化是如何与从起始到延伸再到终止的进程相联系的。
