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聚合物微环谐振器用于高灵敏度和宽频带光声成像。

Polymer microring resonators for high-sensitivity and wideband photoacoustic imaging.

机构信息

Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, USA.

出版信息

IEEE Trans Ultrason Ferroelectr Freq Control. 2009 Nov;56(11):2482-91. doi: 10.1109/TUFFC.2009.1335.


DOI:10.1109/TUFFC.2009.1335
PMID:19942534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2848162/
Abstract

Polymer microring resonators have been exploited for high-sensitivity and wideband photoacoustic imaging. To demonstrate high-sensitivity ultrasound detection, highfrequency photoacoustic imaging of a 49-microm-diameter black bead at an imaging depth of 5 mm was imaged photoacoustically using a synthetic 2-D array with 249 elements and a low laser fluence of 0.35 mJ/cm(2). A bandpass filter with a center frequency of 28 MHz and a bandwidth of 16 MHz was applied to all element data but without signal averaging, and a signal-to-noise ratio of 16.4 dB was obtained. A wideband detector response is essential for imaging reconstruction of multiscale objects, e.g., various sizes of tissues, by using a range of characteristic acoustic wavelengths. A simulation of photoacoustic tomography of beads shows that objects with their boundaries characteristic of high spatial frequencies and the inner structure primarily of low spatial frequency components can be faithfully reconstructed using such a detector. Photoacoustic tomography experiments of 49- and 301-microm-diameter beads were presented. A high resolution of 12.5 microm was obtained. The boundary of a 301-microm bead was imaged clearly. The results demonstrated that the high sensitivity and broadband response of polymer microring resonators have potential for high resolution and high-fidelity photoacoustic imaging.

摘要

聚合物微环谐振器已被用于高灵敏度和宽带光声成象。为了演示高灵敏度的超声检测,使用具有 249 个元件的合成 2-D 阵列和低激光强度 0.35 mJ/cm(2),对位于 5mm 成像深度处的 49μm 直径黑珠进行高频光声成像。将中心频率为 28MHz 且带宽为 16MHz 的带通滤波器应用于所有元件数据,但不进行信号平均,得到的信噪比为 16.4dB。宽带探测器响应对于通过使用各种特征声波波长对多尺度物体(例如各种尺寸的组织)的成像重建是必不可少的。珠子的光声断层扫描模拟表明,使用这种探测器可以忠实地重建具有高空间频率特征边界和主要由低空间频率分量组成的内部结构的物体。还呈现了 49μm 和 301μm 直径珠子的光声断层扫描实验。获得了 12.5μm 的高分辨率。清晰地对 301μm 珠子的边界进行了成像。结果表明,聚合物微环谐振器的高灵敏度和宽带响应有可能实现高分辨率和高保真度的光声成像。

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本文引用的文献

[1]
Polymer Microring Resonators for High-Frequency Ultrasound Detection and Imaging.

IEEE J Sel Top Quantum Electron. 2008-1

[2]
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Opt Express. 2006-10-2

[3]
Low-noise wideband ultrasound detection using polymer microring resonators.

Appl Phys Lett. 2008-5-12

[4]
Characterization of a polymer film optical fiber hydrophone for use in the range 1 to 20 MHz: a comparison with PVDF needle and membrane hydrophones.

IEEE Trans Ultrason Ferroelectr Freq Control. 2000

[5]
Intravascular photoacoustic imaging using an IVUS imaging catheter.

IEEE Trans Ultrason Ferroelectr Freq Control. 2007-5

[6]
High-frequency ultrasound sensors using polymer microring resonators.

IEEE Trans Ultrason Ferroelectr Freq Control. 2007-5

[7]
Imaging acute thermal burns by photoacoustic microscopy.

J Biomed Opt. 2006

[8]
In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy.

J Biomed Opt. 2006

[9]
Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography.

J Biomed Opt. 2006

[10]
Development of a 35-MHz piezo-composite ultrasound array for medical imaging.

IEEE Trans Ultrason Ferroelectr Freq Control. 2006-1

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