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老年人肥胖悖论:潜在机制与临床意义。

The obesity paradox in the elderly: potential mechanisms and clinical implications.

机构信息

Department of Clinical Epidemiology, School of Public Health, University of Alberta, 2F1.26 Walter C Mackenzie HSC, 8440-112 Street, Edmonton, Alberta, Canada.

出版信息

Clin Geriatr Med. 2009 Nov;25(4):643-59, viii. doi: 10.1016/j.cger.2009.07.005.

DOI:10.1016/j.cger.2009.07.005
PMID:19944265
Abstract

The prevalence of overweight and obesity in the elderly has become a growing concern. Recent evidence indicates that in the elderly, obesity is paradoxically associated with a lower, not higher, mortality risk. Although obesity in the general adult population is associated with higher mortality, this relationship is unclear for persons of advanced age and has lead to great controversy regarding the relationship between obesity and mortality in the elderly, the definition of obesity in the elderly, and the need for its treatment in this population. This article examines the evidence on these controversial issues, explores potential explanations for these findings, discusses the clinical implications, and provides recommendations for further research in this area.

摘要

超重和肥胖在老年人中的流行已成为一个日益严重的问题。最近的证据表明,在老年人中,肥胖与较低而不是较高的死亡率相关。尽管在一般成年人群中肥胖与更高的死亡率相关,但在高龄人群中这种关系并不明确,这导致了肥胖与老年人死亡率之间的关系、老年人肥胖的定义以及在该人群中治疗肥胖的必要性等方面的巨大争议。本文研究了这些有争议问题的证据,探讨了这些发现的潜在解释,讨论了其临床意义,并为该领域的进一步研究提供了建议。

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