针刺入的镇痛效果：一项双盲交叉研究。
Analgesic effect of acupuncture needle penetration: a double-blind crossover study.
作者信息
Takakura Nobuari, Yajima Hiroyoshi
出版信息
Open Med. 2009 May 19;3(2):e54-61.
BACKGROUND
Double-blind evaluation of acupuncture treatment has not previously been reported. We investigated the possible advantage of analgesic effects of needle penetration compared with skin pressure using non-penetrating needles in a double-blind study.
METHODS
We conducted a double-blind crossover study of penetrating and non-penetrating (placebo) acupuncture trials. We recruited 56 healthy volunteers. They received painful electrical stimulation in the forearm for 1 minute before and immediately after and 10 minutes after each needle insertion to the LI-4 point, as well as 1 minute before, immediately after, and 10, 20, 30 and 40 minutes after the removal of the needle, which had remained in place for 20 minutes. After each application of electrical stimulation, the subjects rated the pain intensity using a numeric rating scale (0-150) comparing it with the baseline pain intensity (100) before the needle was applied. Pain from skin penetration and deep, dull pain (de qi) associated with needle application, which is considered essential for achieving successful acupuncture analgesia, were also recorded.
RESULTS
We found no significant difference in analgesic effects between the penetrating and non-penetrating needle trials. In addition, no significant correlation was found between analgesic effect and de qi. A significant analgesic effect was observed during needle application and immediately after needle removal for both the penetrating and non-penetrating needle trials when compared with the no-acupuncture control condition (penetrating v. control: immediately, 10 minutes and 20 minutes after needle insertion [p < 0.001 for each] and immediately, 10 minutes and 20 minutes after needle removal [p < 0.050] for each; non-penetrating v. control: immediately, 10 minutes and 20 minutes after needle insertion [p < 0.001 for each] and immediately after needle removal [p = 0.010]).
INTERPRETATION
Needle penetration did not confer a specific analgesic advantage over non-penetrating (placebo) needle application.
背景
此前尚未有关于针刺治疗双盲评估的报道。我们在一项双盲研究中，研究了与使用非穿透性针施加皮肤压力相比，针刺入的镇痛效果可能具有的优势。
方法
我们对穿透性和非穿透性（安慰剂）针刺试验进行了双盲交叉研究。我们招募了56名健康志愿者。在每次将针插入合谷穴之前1分钟、插入后立即以及插入后10分钟，他们的前臂会接受1分钟的疼痛性电刺激，并且在针留置20分钟后拔除，在拔除前1分钟、拔除后立即以及拔除后10、20、30和40分钟，他们的前臂也会接受疼痛性电刺激。每次施加电刺激后，受试者使用数字评分量表（0 - 150）对疼痛强度进行评分，并将其与针刺前的基线疼痛强度（100）进行比较。还记录了皮肤穿透引起的疼痛以及与针刺相关的深部钝痛（得气），得气被认为是实现成功针刺镇痛所必需的。
结果
我们发现穿透性和非穿透性针试验在镇痛效果上没有显著差异。此外，在镇痛效果与得气之间未发现显著相关性。与无针刺对照情况相比，在穿透性和非穿透性针试验中，针刺期间以及拔除针后立即观察到显著的镇痛效果（穿透性与对照：针刺后立即、10分钟和20分钟 [每次p < 0.001] 以及拔除针后立即、10分钟和20分钟 [每次p < 0.050]；非穿透性与对照：针刺后立即、10分钟和20分钟 [每次p < 0.001] 以及拔除针后立即 [p = 0.010]）。
解读
与非穿透性（安慰剂）针刺相比，针刺入并未赋予特定的镇痛优势。
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