皮肤接触式假针并非安慰剂？一项关于疼痛缓解的双盲交叉研究。
Is Skin-Touch Sham Needle Not Placebo? A Double-Blind Crossover Study on Pain Alleviation.
作者信息
Takayama Miho, Yajima Hiroyoshi, Kawase Akiko, Homma Ikuo, Izumizaki Masahiko, Takakura Nobuari
机构信息
Department of Acupuncture and Moxibustion, Faculty of Health Sciences, Tokyo Ariake University of Medical and Health Sciences, 2-9-1 Ariake, Koto-ku, Tokyo 135-0063, Japan ; Department of Physiology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan ; Japan School of Acupuncture, Moxibustion and Physiotherapy, 20-1 Sakuragaokacho, Shibuya-ku, Tokyo 150-0031, Japan ; The Foundation for Oriental Medicine Research, 28-9 Sakuragaokacho, Shibuya-ku, Tokyo 150-0031, Japan.
Department of Physiology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan ; Japan School of Acupuncture, Moxibustion and Physiotherapy, 20-1 Sakuragaokacho, Shibuya-ku, Tokyo 150-0031, Japan ; The Foundation for Oriental Medicine Research, 28-9 Sakuragaokacho, Shibuya-ku, Tokyo 150-0031, Japan.
出版信息
Evid Based Complement Alternat Med. 2015;2015:152086. doi: 10.1155/2015/152086. Epub 2015 May 7.
It remains an open question whether placebo/sham acupuncture, in which the needle tip presses the skin, can be used as a placebo device for research on pain. We compare the analgesic effect of the skin-touch placebo needle with that of the no-touch placebo needle, in which the needle tip does not touch the skin, in a double-blind crossover manner including no-treatment control in 23 healthy volunteers. The subjects received painful electrical stimulation in the forearm before and during needle retention to the LI 4 acupoint and after the removal of the needle and rated pain intensity using a visual analogue scale. We found no significant difference in analgesic effects among the skin-touch placebo needle, no-touch placebo needle, and no-treatment control at every point before, during, and after the treatments (p > 0.05). The results indicate that the skin-touch placebo needle can be used as a placebo device in clinical studies on pain.
针刺尖端仅按压皮肤的安慰剂/假针刺是否可用作疼痛研究的安慰剂装置仍是一个悬而未决的问题。我们采用双盲交叉方式，在23名健康志愿者中，将皮肤接触式安慰剂针与针尖端不接触皮肤的非接触式安慰剂针的镇痛效果进行比较，同时设置了无治疗对照组。受试者在针刺留针至合谷穴之前、留针期间、拔针后，均在前臂接受疼痛性电刺激，并使用视觉模拟量表对疼痛强度进行评分。我们发现，在治疗前、治疗期间和治疗后的每个时间点，皮肤接触式安慰剂针、非接触式安慰剂针和无治疗对照组之间的镇痛效果均无显著差异（p>0.05）。结果表明，皮肤接触式安慰剂针可作为疼痛临床研究中的安慰剂装置。
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