Sporik R, Johnstone J H, Cogswell J J
Poole General Hospital, Poole Dorset.
Arch Dis Child. 1991 Jan;66(1):134-7. doi: 10.1136/adc.66.1.134.
Sixty eight children born in 1977 who were taking part in an unrelated study of childhood asthma were selected to have their serum cholesterol concentrations measured at birth, and at 4 months and 1, 2, 3, 4, 5, and 11 years of age. Concentrations of high density lipoprotein were measured at 5 and 11 years. Cholesterol values increased rapidly from birth and plateaued at 1 year. There was a further small rise just before puberty. Tracking of values was seen after the age of 1 year, but did not become established until 4 years of age. The cholesterol concentrations in girls were marginally higher than those in boys. The mean (SD) values of cholesterol (mmol/l) for boys were: at birth, 1.7 (0.4); at 1 year, 3.9 (0.9); at 5 years, 5.2 (1.9); and at 11 years, 5.0 (0.7). For girls the corresponding figures were; at birth, 1.9 (0.6); at 1 year, 4.7 (1.0); at 5 years, 4.6 (0.7); and at 11 years, 5.1 (0.7). The mean (SD) high density lipoprotein concentrations (mmol/l) for boys were: at 5, 1.16 (0.35) and at 11, 1.51 (0.23). For girls they were 1.28 (0.30) and 1.56 (0.27), respectively. The serum cholesterol concentrations in these children were high compared with published figures from north America.
1977年出生的68名参与一项无关的儿童哮喘研究的儿童被选取，测量他们出生时、4个月大时以及1、2、3、4、5和11岁时的血清胆固醇浓度。在5岁和11岁时测量高密度脂蛋白浓度。胆固醇值从出生起迅速上升，并在1岁时趋于平稳。青春期前有进一步的小幅上升。1岁后可见数值的追踪，但直到4岁才稳定下来。女孩的胆固醇浓度略高于男孩。男孩胆固醇（mmol/l）的平均（标准差）值为：出生时1.7（0.4）；1岁时3.9（0.9）；5岁时5.2（1.9）；11岁时5.0（0.7）。女孩的相应数字为：出生时1.9（0.6）；1岁时4.7（1.0）；5岁时4.6（0.7）；11岁时5.1（0.7）。男孩高密度脂蛋白浓度（mmol/l）的平均（标准差）值为：5岁时1.16（0.35），11岁时1.51（0.23）。女孩的分别为1.28（0.30）和1.56（0.27）。与北美公布的数据相比，这些儿童的血清胆固醇浓度较高。
