Lin Yu-Cheng, Chang Pi-Feng, Hu Fu-Chang, Chang Mei-Hwei, Ni Yen-Hsuan
Department of Pediatrics, Far Eastern Memorial Hospital, Taipei, Taiwan.
Pediatrics. 2009 Dec;124(6):e1221-7. doi: 10.1542/peds.2008-3087.
Oxidative stress is increased in nonalcoholic fatty liver disease (NAFLD). Variants in the UGT1A1 gene contribute to increased bilirubin levels, and bilirubin can act as an antioxidant. We hypothesize that variant UGT1A1 genotypes reduce the risk for NAFLD development.
Two hundred thirty-four obese children 6 to 13 years of age were recruited. NAFLD was determined through liver ultrasonography. The UGT1A1 genotypes UGT1A16 and UGT1A128 were detected. We assessed the effects of UGT1A1 genotypes on pediatric NAFLD.
In total, 12% of the obese children had NAFLD. The subjects with NAFLD had lower serum total bilirubin levels (0.25 +/- 0.30 mg/dL) than did those without NAFLD (0.36 +/- 0.38 mg/dL; P = .021). With conditioning on the effects of age- and gender-adjusted BMI, waist/hip ratio, and adiponectin levels, variant UGT1A16 genotypes were a protecting factor for NAFLD, with an estimated adjusted odds ratio of 0.31 (95% confidence interval: 0.11-0.91; P = .033), but variant UGT1A128 genotypes were not significantly associated with the occurrence of NAFLD.
Variant UGT1A1*6 genotypes are associated with a lower risk of NAFLD in obese Taiwanese children. The UGT1A1 genotype is a new risk factor for pediatric NAFLD.
非酒精性脂肪性肝病（NAFLD）中氧化应激增加。UGT1A1基因的变异会导致胆红素水平升高，而胆红素可作为一种抗氧化剂。我们推测UGT1A1基因变异型基因型可降低NAFLD发生风险。
招募了234名6至13岁的肥胖儿童。通过肝脏超声检查确定是否患有NAFLD。检测UGT1A1基因型UGT1A16和UGT1A128。我们评估了UGT1A1基因型对儿童NAFLD的影响。
总共有12%的肥胖儿童患有NAFLD。患有NAFLD的受试者血清总胆红素水平（0.25±0.30mg/dL）低于未患NAFLD的受试者（0.36±0.38mg/dL；P = 0.021）。在对年龄、性别调整后的体重指数、腰臀比和脂联素水平的影响进行校正后，UGT1A16基因变异型基因型是NAFLD的一个保护因素，估计校正比值比为0.31（95%置信区间：0.11 - 0.91；P = 0.033），但UGT1A128基因变异型基因型与NAFLD的发生无显著相关性。
UGT1A1*6基因变异型基因型与台湾肥胖儿童患NAFLD的风险较低相关。UGT1A1基因型是儿童NAFLD的一个新的风险因素。
