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在南非约翰内斯堡接受抗逆转录病毒治疗的外国人中取得了良好的治疗效果。

Good treatment outcomes among foreigners receiving antiretroviral therapy in Johannesburg, South Africa.

作者信息

McCarthy K, Chersich M F, Vearey J, Meyer-Rath G, Jaffer A, Simpwalo S, Venter W D F

机构信息

Reproductive Health and HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.

出版信息

Int J STD AIDS. 2009 Dec;20(12):858-62. doi: 10.1258/ijsa.2009.009258.

DOI:10.1258/ijsa.2009.009258
PMID:19948901
Abstract

Foreigners, including displaced persons, often have limited health-care access, especially to HIV services. Outcomes of antiretroviral therapy (ART) in South Africans and foreigners were compared at a Johannesburg non-governmental clinic. Records were reviewed of 1297 adults enrolled between April 2004 and March 2007 (568 self-identified foreigners, 431 South Africans citizens and 298 with unknown origin). Compared with citizens, foreigners had fewer hospital admissions (39%, 90/303 versus 51%, 126/244; P < 0.001), less missed appointments for ART initiation (20%, 39/200 versus 25%, 51/206; P < 0.001), faster median time to ART initiation (14 versus 21 days, P = 0.008), better retention in care (88%, 325/369 versus 69%, 155/226; P < 0.001) and lower mortality (2.5%, 14/568 versus 10%, 44/431; P < 0.001) after 426 person-years. In logistic regression, after controlling for baseline CD4 count and tuberculosis status, foreigners were 55% less likely to fail ART than citizens (95% CI = 0.23-0.87). These findings support United Nations High Commissioner for Refugees recommendations that ART should not be withheld from displaced persons.

摘要

包括流离失所者在内的外国人往往获得医疗保健的机会有限,尤其是获得艾滋病毒服务的机会。在约翰内斯堡的一家非政府诊所,对南非人和外国人接受抗逆转录病毒疗法(ART)的结果进行了比较。回顾了2004年4月至2007年3月期间登记的1297名成年人的记录(568名自称外国人、431名南非公民和298名来源不明者)。与公民相比,外国人住院次数较少(39%,90/303对51%,126/244;P<0.001),开始接受抗逆转录病毒治疗时错过预约的情况较少(20%,39/200对25%,51/206;P<0.001),开始接受抗逆转录病毒治疗的中位时间更快(14天对21天,P=0.008),护理留存率更高(88%,325/369对69%,155/226;P<0.001),426人年之后死亡率更低(2.5%,14/568对10%,44/431;P<0.001)。在逻辑回归中,在控制基线CD4细胞计数和结核病状况后,外国人抗逆转录病毒治疗失败的可能性比公民低55%(95%CI=0.23-0.87)。这些发现支持了联合国难民事务高级专员的建议,即不应拒绝对流离失所者提供抗逆转录病毒治疗。

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