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体重增加,年轻化:生命历程中的肥胖轨迹。

Getting heavier, younger: trajectories of obesity over the life course.

机构信息

Division of Pediatric Endocrinology, University of Michigan, Ann Arbor, MI 48109-5456, USA.

出版信息

Int J Obes (Lond). 2010 Apr;34(4):614-23. doi: 10.1038/ijo.2009.235. Epub 2009 Dec 1.

Abstract

CONTEXT

Although recent trends in obesity have been well documented, generational patterns of obesity from early childhood through adulthood across birth cohorts, which account for the recent epidemic of childhood obesity, have not been well described. Such trends may have implications for the prevalence of obesity-associated conditions among population subgroups, including type 2 diabetes.

OBJECTIVE

Our objective was to evaluate trajectories of obesity over the life course for the US population, overall and by gender and race.

DESIGN, SETTING AND PARTICIPANTS: We conducted an age, period and birth cohort analysis of obesity for US individuals who participated in the National Health and Nutrition Examination Surveys (NHANES) (1971-2006).

MAIN OUTCOME MEASURES

Obesity was defined as a body mass index >or=95th percentile for individuals aged 2-16 years or >or=30 kg m(-2) among individuals older than 16 years. Age was represented by the age of the individual at each NHANES, period was defined by the year midpoint of each survey, and cohort was calculated by subtracting age from period.

RESULTS

Recent birth cohorts are becoming obese in greater proportions for a given age, and are experiencing a greater duration of obesity over their lifetime. For example, although the 1966-1975 and 1976-1985 birth cohorts had reached an estimated obesity prevalence of at least 20% by 20-29 years of age, this level was only reached by 30-39 years for the 1946-1955 and 1956-1965 birth cohorts, by 40-49 years for the 1936-1945 birth cohort and by 50-59 years of age for the 1926-1935 birth cohort. Trends are particularly pronounced for female compared with male, and black compared with white cohorts.

CONCLUSIONS

The increasing cumulative exposure to excess weight over the lifetime of recent birth cohorts will likely have profound implications for future rates of type 2 diabetes, and mortality within the US population.

摘要

背景

尽管最近肥胖趋势已经得到充分记录,但从儿童期到成年期的各出生队列中,肥胖的代际模式——这是儿童肥胖最近流行的原因——尚未得到充分描述。这些趋势可能对包括 2 型糖尿病在内的人群亚组中肥胖相关疾病的患病率产生影响。

目的

我们的目的是评估美国人群一生中肥胖的轨迹,包括按性别和种族进行的评估。

设计、地点和参与者:我们对参加国家健康和营养检查调查(NHANES)(1971-2006 年)的美国个体进行了年龄、时期和出生队列肥胖分析。

主要观察指标

肥胖的定义是个体在 2-16 岁时的体质指数大于等于第 95 百分位数,或个体年龄大于 16 岁时大于等于 30kg/m²。年龄由 NHANES 中个体的年龄表示,时期由每次调查的中点年份定义,队列由时期减去年龄计算。

结果

最近的出生队列在给定年龄时肥胖的比例越来越高,并且一生中肥胖的持续时间也越来越长。例如,尽管 1966-1975 年和 1976-1985 年出生队列在 20-29 岁时肥胖率估计已达到至少 20%,但 1946-1955 年和 1956-1965 年出生队列仅在 30-39 岁时达到这一水平,1936-1945 年出生队列在 40-49 岁时达到这一水平,1926-1935 年出生队列在 50-59 岁时达到这一水平。与男性相比,女性的趋势尤其明显,与白人相比,黑人的趋势尤其明显。

结论

最近出生队列一生中暴露于超重的累积量不断增加,这可能对美国人口中 2 型糖尿病的未来发病率和死亡率产生深远影响。

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