SULT1A1 R213H 多态性与乳腺癌风险的关联：基于 8454 例病例和 11800 例对照的荟萃分析。
SULT1A1 R213H polymorphism and breast cancer risk: a meta-analysis based on 8,454 cases and 11,800 controls.
机构信息
Department of Epidemiology and Biostatistics, Nanjing Medical University, 210029 Nanjing, China.
出版信息
Breast Cancer Res Treat. 2010 Jul;122(1):193-8. doi: 10.1007/s10549-009-0648-y. Epub 2009 Dec 1.
The SULT1A1 R213H polymorphism is suggested to be implicated in the development and progression of breast cancer. However, the published findings are inconsistent. We therefore performed a meta-analysis of 8,454 breast cancer cases and 11,800 controls from 14 published case-control studies. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association of the R213H polymorphism with breast cancer risk. Overall, our results suggested that there is no significant relationship between SULT1A1 R213H polymorphism and the risk of breast cancer. However, further ethnic population analysis revealed a significantly increased risk of breast cancer for HH allele carriers among Asians (for HH vs. RR: OR = 2.27, 95% CI = 1.11-4.63, P (heterogeneity) = 0.63; for the recessive model: OR = 2.03, 95% CI = 1.00-4.41, P (heterogeneity) = 0.62). Taken together, this meta-analysis suggests that the SULT1A1 R213H may be a low-penetrant risk factor for developing breast cancer in Asian population.
SULT1A1 R213H 多态性被认为与乳腺癌的发生和发展有关。然而，已发表的研究结果并不一致。因此，我们对来自 14 项已发表病例对照研究的 8454 例乳腺癌病例和 11800 例对照进行了荟萃分析。我们使用比值比（ORs）及其 95%置信区间（CIs）来评估 R213H 多态性与乳腺癌风险之间的关联强度。总的来说，我们的结果表明 SULT1A1 R213H 多态性与乳腺癌风险之间没有显著关系。然而，进一步的种族人群分析显示，HH 等位基因携带者患乳腺癌的风险显著增加（对于 HH 与 RR：OR = 2.27，95%CI = 1.11-4.63，P（异质性）= 0.63；对于隐性模型：OR = 2.03，95%CI = 1.00-4.41，P（异质性）= 0.62）。综上所述，这项荟萃分析表明，SULT1A1 R213H 可能是亚洲人群患乳腺癌的低外显度风险因素。
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