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新鲜同种异体骨软骨移植治疗距骨大面积囊性骨软骨缺损

Fresh osteochondral allografts for large-volume cystic osteochondral defects of the talus.

作者信息

Raikin Steven M

出版信息

J Bone Joint Surg Am. 2009 Dec;91(12):2818-26. doi: 10.2106/JBJS.I.00398.

DOI:10.2106/JBJS.I.00398
PMID:19952243
Abstract

BACKGROUND

Large-volume osteochondral lesions of the talus present a difficult dilemma for the treating physician. The purpose of this study was to evaluate the clinical outcomes of talar lesions with a volume of >3000 mm(3) treated with fresh bulk osteochondral allograft transplantation.

METHODS

Fifteen patients (mean age, 41.9 years) who had symptomatic osteochondral lesions of the talus with a mean volume of 6059 mm(3) underwent fresh matched osteochondral allograft transplantation. All patients were followed prospectively for a minimum of two years and were evaluated with use of the pain score on a visual analog scale, which ranged from 0 to 10, and the American Orthopaedic Foot and Ankle Society ankle-hindfoot score, which had a maximum of 100 points. Patient satisfaction and radiographic stability of the graft were also assessed.

RESULTS

All patients were available for follow-up at an average fifty-four months after surgery. Two ankles subsequently underwent conversion to an ankle arthrodesis at thirty-two and seventy-six months, respectively. With the scores for these patients included (at the time of arthrodesis), the mean pain score had improved from 8.5 to 3.3 and the mean American Orthopaedic Foot and Ankle Society ankle-hindfoot score had improved 45 points, from 38 to 83 points. Overall, five patients rated the result as excellent, six as good, two as fair, and two as poor.

CONCLUSIONS

Bulk fresh osteochondral allograft transplantation to the talus is a viable reconstructive option for patients with large-volume cystic lesions of the talar dome. Graft stability and viability are maintained both structurally and functionally over a mean follow-up period of 4.5 years (minimum, two years).

摘要

背景

距骨的大面积骨软骨损伤给治疗医生带来了难题。本研究的目的是评估采用新鲜大块骨软骨异体移植治疗体积>3000立方毫米的距骨损伤的临床疗效。

方法

15例有症状的距骨骨软骨损伤患者(平均年龄41.9岁),平均损伤体积为6059立方毫米,接受了新鲜匹配的骨软骨异体移植。所有患者均接受前瞻性随访至少两年,并使用视觉模拟评分法(范围为0至10分)评估疼痛评分,以及使用美国矫形足踝协会踝 - 后足评分(满分100分)进行评估。还评估了患者满意度和移植骨的影像学稳定性。

结果

所有患者在术后平均54个月时均接受了随访。两个踝关节随后分别在32个月和76个月时进行了踝关节融合术。纳入这些患者(在融合术时)的评分后,平均疼痛评分从8.5分改善至3.3分,美国矫形足踝协会踝 - 后足平均评分提高了45分,从38分提高至83分。总体而言,5例患者将结果评为优秀,6例评为良好,2例评为中等,2例评为差。

结论

对于距骨穹窿部有大面积囊性损伤的患者,大块新鲜骨软骨异体移植到距骨是一种可行的重建选择。在平均4.5年(最短两年)的随访期内,移植骨在结构和功能上均保持了稳定性和活力。

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