The Cooper Institute.
Med Sci Sports Exerc. 2010 Apr;42(4):701-7. doi: 10.1249/MSS.0b013e3181c03a2b.
Elevated C-reactive protein (CRP) is associated with an increased risk of cardiovascular disease. Physical activity has been inversely associated with CRP. However, the clinical trials examining the effect of exercise training have produced conflicting results.
The purpose of this study was to examine the influence an exercise training program on CRP in postmenopausal women.
Sedentary, overweight, or obese postmenopausal women with elevated systolic blood pressure (120-160 mm Hg; n = 464) were randomized into one of four groups: a nonexercise control or one of three aerobic exercise groups; exercise energy expenditure of 4, 8, or 12 kcal·kg(-1)·wk(-1) (KKW) for 6 months at a training intensity of 50% of peak VO2.
Complete data for 421 participants were available, and mean (SD) baseline CRP was 5.7 (5.5) mg·L(-1), with no significant differences across groups. Although VO2 increased in a dose-response manner, there were no significant changes in CRP in any of the exercise intervention groups compared with the control group. Change in fitness was not associated with change in CRP, whereas change in weight was significantly associated with change in CRP.
Despite increasing fitness, 6 months of aerobic exercise training did not improve CRP. However, improvements in CRP were associated with reductions in weight.
C 反应蛋白（CRP）升高与心血管疾病风险增加有关。身体活动与 CRP 呈负相关。然而，检查运动训练效果的临床试验得出了相互矛盾的结果。
本研究旨在探讨运动训练计划对绝经后妇女 CRP 的影响。
久坐、超重或肥胖、收缩压升高（120-160mmHg；n=464）的绝经后妇女随机分为四组：非运动对照组或三组有氧运动组之一；运动能量消耗为 4、8 或 12kcal·kg(-1)·wk(-1)，训练强度为峰值 VO2 的 50%，持续 6 个月。
421 名参与者中有完整数据，平均（SD）基线 CRP 为 5.7（5.5）mg·L(-1)，各组间无显著差异。尽管 VO2 呈剂量反应方式增加，但与对照组相比，任何运动干预组的 CRP 均无明显变化。体能的变化与 CRP 的变化无关，而体重的变化与 CRP 的变化显著相关。
尽管体能有所提高，但 6 个月的有氧运动训练并未改善 CRP。然而，CRP 的改善与体重的减轻有关。
