Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808-4124, USA.
Med Sci Sports Exerc. 2010 Apr;42(4):708-16. doi: 10.1249/MSS.0b013e3181c03a43.
Numerous cross-sectional studies have observed an inverse association between C-reactive protein (CRP) and physical activity. Exercise training trials have produced conflicting results, but none of these studies was specifically designed to examine CRP. The objective of the Inflammation and Exercise (INFLAME) study was to examine whether aerobic exercise training without dietary intervention can reduce CRP in individuals with elevated CRP.
The study was a randomized controlled trial of 162 sedentary men and women with elevated CRP (> or = 2.0 mg·L(-1)). Participants were randomized into a nonexercise control group or an exercise group that trained for 4 months. The primary outcome was change in CRP.
The study participants had a mean (SD) age of 49.7 (10.9) yr and a mean body mass index of 31.8 (4.0) kg·m(-2). The median (interquartile range (IQR)) and mean baseline CRP levels were 4.1 (2.5-6.1) and 4.8 (3.4) mg·L(-1), respectively. In the exercise group, median exercise compliance was 99.9%. There were no differences in median (IQR) change in CRP between the control and exercise groups (0.0 (-0.5 to 0.9) vs 0.0 (-0.8 to 0.7) mg·L(-1), P = 0.4). The mean (95% confidence interval) change in CRP adjusted for gender and baseline weight was similar in the control and exercise groups, with no significant difference between groups (0.5 (-0.4 to 1.3) vs 0.4 (-0.5 to 1.2) mg·L(-1), P = 0.9). Change in weight was correlated with change in CRP.
Exercise training without weight loss is not associated with a reduction in CRP.
大量的横断面研究观察到 C 反应蛋白（CRP）与身体活动之间呈负相关。运动训练试验得出了相互矛盾的结果，但这些研究中没有一项专门设计用于检查 CRP。炎症与运动（INFLAME）研究的目的是研究在没有饮食干预的情况下，有氧运动训练是否可以降低 CRP 升高的个体的 CRP。
这是一项针对 162 名 CRP 升高（> 或 = 2.0 mg·L（-1））的久坐男性和女性的随机对照试验。参与者被随机分为非运动对照组或运动组，运动组进行了 4 个月的训练。主要结局是 CRP 的变化。
研究参与者的平均（SD）年龄为 49.7（10.9）岁，平均体重指数为 31.8（4.0）kg·m（-2）。中位数（四分位间距（IQR））和平均基线 CRP 水平分别为 4.1（2.5-6.1）和 4.8（3.4）mg·L（-1）。在运动组中，中位数运动依从性为 99.9%。对照组和运动组的 CRP 中位数（IQR）变化无差异（0.0（-0.5 至 0.9）与 0.0（-0.8 至 0.7）mg·L（-1），P = 0.4）。在性别和基线体重校正后，CRP 的平均（95%置信区间）变化在对照组和运动组中相似，两组之间无显著差异（0.5（-0.4 至 1.3）与 0.4（-0.5 至 1.2）mg·L（-1），P = 0.9）。体重的变化与 CRP 的变化相关。
不减轻体重的运动训练与 CRP 降低无关。
