Molecular Biotechnology Laboratory, Hokkaido Animal Research Center, Shintoku, Hokkaido, Japan.
Microbiol Immunol. 2009 Dec;53(12):704-7. doi: 10.1111/j.1348-0421.2009.00169.x.
It has been assumed that the agent causing BSE in cattle is a uniform strain (classical BSE); however, different neuropathological and molecular phenotypes of BSE (atypical BSE) have been recently reported. We demonstrated the successful transmission of L-type-like atypical BSE detected in Japan (BSE/JP24 isolate) to cattle. Based on the incubation period, neuropathological hallmarks, and molecular properties of the abnormal host prion protein, the characteristics of BSE/JP24 prion were apparently distinguishable from the classical BSE prion and closely resemble those of bovine amyloidotic spongiform encephalopathy prion detected in Italy.
人们一直认为引起牛海绵状脑病的病原体是一种均一的毒株（经典型 BSE）；然而，最近报道了 BSE 的不同神经病理学和分子表型（非典型 BSE）。我们已经证明，日本（BSE/JP24 分离株）中检测到的 L 型类似非典型 BSE 可以成功地在牛中传播。基于潜伏期、神经病理学特征和异常宿主朊病毒蛋白的分子特性，BSE/JP24 朊病毒的特征明显有别于经典型 BSE 朊病毒，与在意大利检测到的牛海绵状脑病朊病毒相似。
