Jhaveri K D, Aelion A, Wanchoo R
Department of Nephrology and Hypertension, Weill Cornell Medical Center, New York, Presbyterian Hospital, 525 East 68th Street, New York NY 10021, USA.
Clin Nephrol. 2009 Dec;72(6):492-6.
Pre-eclampsia affects 5 - 8% of pregnancies in the USA and 3 - 14% of pregnancies worldwide. Classically, the syndrome includes hypertension and proteinuria that may be associated with edema, headache and worsening epigastric pain. This is postulated from vasospasm and endothelial cell damage. Hyponatremia in pre-eclamptic pregnancies has been described in few cases, most of which were twin pregnancies, and four of them had nephrotic syndrome. The management of hyponatremia requires a multidisciplinary approach and significant attention, as this condition can predispose to convulsions along with pre-eclampsia, thus, endangering the life of the mother and the child. We describe a case of a patient who developed pre-eclampsia and hyponatremia in the absence of proteinuria, at 34 weeks of a twin pregnancy; there was progression to oliguria with complete remission following delivery by cesarean section.
在美国,子痫前期影响5%至8%的妊娠,在全球范围内影响3%至14%的妊娠。典型地,该综合征包括高血压和蛋白尿,可能伴有水肿、头痛和上腹部疼痛加重。这是由血管痉挛和内皮细胞损伤推测而来的。子痫前期妊娠合并低钠血症的病例很少被描述,其中大多数是双胎妊娠,并且其中4例患有肾病综合征。低钠血症的管理需要多学科方法并给予高度关注,因为这种情况可能会导致子痫前期抽搐,从而危及母婴生命。我们描述了一例双胎妊娠34周时在无蛋白尿情况下发生子痫前期和低钠血症的患者病例;病情进展为少尿,剖宫产分娩后完全缓解。