Howard Hughes Medical Institute and UCSF Biochemistry and Biophysics, 1700 4th St., QB3 Room 403, San Francisco, CA 94143-2542, USA.
J Virol. 2010 Feb;84(4):2176-9. doi: 10.1128/JVI.02191-09. Epub 2009 Dec 2.
A proventricular dilatation disease (PDD) outbreak provided the opportunity to investigate the transmissibility of avian Bornavirus (ABV) and its linkage to PDD under natural conditions. Upon exposure to a bird with a fatal case of PDD, 10 birds became symptomatic and died. ABV2 RNA was recovered from available tissues. Further screening revealed that 12/46 exposed birds were ABV2(+). Three chicks boarded at this aviary developed PDD. They harbored the same ABV2 isolate and transmitted it to five of eight chicks in their home aviary. These findings demonstrate that ABV infection precedes the development of PDD. ABV-specific Western blotting and reverse transcription-PCR indicate that ABV2 is not strictly neurotropic.
一种前胃扩张病（PDD）的爆发为研究禽传染性支气管炎病毒（ABV）在自然条件下的传染性及其与 PDD 的关系提供了机会。在接触到一只患有致命 PDD 的鸟后，有 10 只鸟出现症状并死亡。从可用组织中回收了 ABV2 RNA。进一步筛选显示，46 只暴露的鸟中有 12 只 ABV2(+)。三只在这个鸟舍饲养的小鸡患上了 PDD。它们携带了相同的 ABV2 分离株，并将其传播给了家中鸟舍的 8 只小鸡中的 5 只。这些发现表明，ABV 感染先于 PDD 的发展。ABV 特异性 Western blot 和逆转录-PCR 表明 ABV2 并非严格的嗜神经性。
