脑脊液中的 8-OHdG 作为各种神经退行性疾病氧化应激的标志物。
8-OHdG in cerebrospinal fluid as a marker of oxidative stress in various neurodegenerative diseases.
机构信息
Department of Neurology, Georg August University, DE-37075 Goettingen, Germany.
出版信息
Neurodegener Dis. 2009;6(5-6):263-9. doi: 10.1159/000237221. Epub 2009 Dec 3.
BACKGROUND
The 8-hydroxy-2 deoxyguanosine (8-OHdG) is a product of nucleoside oxidation of DNA and a reliable marker of oxidative stress markers. Increased levels of oxidative stress have been reported in the cerebrospinal fluid (CSF) of patients with various neurodegenerative disorders.
OBJECTIVE
In search of a biochemical indicator of Parkinson's disease (PD), we analyzed the levels 8-OHdG in the CSF of 99 patients, using ELISA to assess the differences between various neurodegenerative disorders.
RESULTS
Statistically significant higher CSF levels (p = 0.022) of 8-OHdG in non-demented PD patients as compared to the control group were observed. No differences between CSF 8-OHdG levels and age at the time of lumbar puncture, presence or severity of dementia, or gender were found.
CONCLUSIONS
8-OHdG levels could be potentially useful in the neurochemically supported diagnosis of PD.
背景
8-羟基-2-脱氧鸟苷（8-OHdG）是 DNA 核苷氧化的产物，也是氧化应激标志物的可靠标志物。已有报道称，各种神经退行性疾病患者的脑脊液（CSF）中氧化应激水平升高。
目的
为寻找帕金森病（PD）的生化指标，我们使用 ELISA 分析了 99 例患者 CSF 中的 8-OHdG 水平，以评估各种神经退行性疾病之间的差异。
结果
与对照组相比，非痴呆型 PD 患者 CSF 中 8-OHdG 的水平显著升高（p = 0.022）。未发现 CSF 8-OHdG 水平与腰椎穿刺时的年龄、痴呆的存在或严重程度或性别之间存在差异。
结论
8-OHdG 水平可能对支持神经化学诊断 PD 有用。
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