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脊髓运动的活动依赖性可塑性:对感觉处理的影响。

Activity-dependent plasticity of spinal locomotion: implications for sensory processing.

机构信息

Department of Physiological Science, Brain Research Institute, University of California, Los Angeles, 90095, USA.

出版信息

Exerc Sport Sci Rev. 2009 Oct;37(4):171-8. doi: 10.1097/JES.0b013e3181b7b932.

DOI:10.1097/JES.0b013e3181b7b932
PMID:19955866
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2790155/
Abstract

The lumbosacral spinal cord of mammals contains the neural circuitry capable of generating full weight-bearing locomotion of the hind limbs without any supraspinal input. One or more interventions, for example, pharmacological, epidural stimulation, and/or locomotor training, however, are necessary to gain access to and modulate the properties of this circuitry and to facilitate recovery of full weight-bearing locomotion after spinal cord injury.

摘要

哺乳动物的腰骶脊髓包含有生成无需任何上位神经输入的完整负重后肢运动的神经回路。然而,需要一种或多种干预措施,例如药理学、硬膜外刺激和/或运动训练,以获得对该回路的特性进行调节,并促进脊髓损伤后完全负重运动的恢复。

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本文引用的文献

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Locomotor training maintains normal inhibitory influence on both alpha- and gamma-motoneurons after neonatal spinal cord transection.运动训练可维持正常的抑制作用,对阿尔法和伽玛运动神经元后新生儿脊髓切断。
J Neurosci. 2011 Jan 5;31(1):26-33. doi: 10.1523/JNEUROSCI.6433-09.2011.
2
Effects of H-reflex up-conditioning on GABAergic terminals on rat soleus motoneurons.H反射上行条件化对大鼠比目鱼肌运动神经元上γ-氨基丁酸能终末的影响。
Eur J Neurosci. 2008 Aug;28(4):668-74. doi: 10.1111/j.1460-9568.2008.06370.x. Epub 2008 Jul 24.
3
Step training reinforces specific spinal locomotor circuitry in adult spinal rats.
在次最大强度测力计蹬踏的重复过程中,自由选择的踏频增加。
Int J Exerc Sci. 2022 Aug 1;15(1):1142-1155. doi: 10.70252/PQEW7182. eCollection 2022.
4
Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation.通过支架新再生的轴突在硬膜外电刺激下促进损伤部位以下的重组和运动恢复。
NPJ Regen Med. 2021 Oct 20;6(1):66. doi: 10.1038/s41536-021-00176-6.
5
Eccentric rehabilitation induces white matter plasticity and sensorimotor recovery in chronic spinal cord injury.离心康复诱导慢性脊髓损伤的白质可塑性和运动感觉功能恢复。
Exp Neurol. 2021 Dec;346:113853. doi: 10.1016/j.expneurol.2021.113853. Epub 2021 Aug 28.
6
Effects of Multi-Muscle Electrical Stimulation and Stand Training on Stepping for an Individual With SCI.多肌肉电刺激和站立训练对脊髓损伤个体步行的影响。
Front Hum Neurosci. 2020 Sep 25;14:549965. doi: 10.3389/fnhum.2020.549965. eCollection 2020.
7
Varied movement errors drive learning of dynamic balance control during walking in people with incomplete spinal cord injury: a pilot study.不同的运动误差驱动不完全性脊髓损伤患者行走时动态平衡控制的学习:一项初步研究。
Exp Brain Res. 2020 Apr;238(4):981-993. doi: 10.1007/s00221-020-05776-0. Epub 2020 Mar 18.
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Front Syst Neurosci. 2020 Jan 15;13:82. doi: 10.3389/fnsys.2019.00082. eCollection 2019.
9
The recovery of standing and locomotion after spinal cord injury does not require task-specific training.脊髓损伤后站立和行走的恢复不需要特定于任务的训练。
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10
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Behav Brain Res. 2007 Jun 4;180(1):95-101. doi: 10.1016/j.bbr.2007.02.029. Epub 2007 Feb 25.
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10
Is spinal cord isolation a good model of muscle disuse?脊髓隔离是肌肉废用的良好模型吗?
Muscle Nerve. 2007 Mar;35(3):312-21. doi: 10.1002/mus.20706.