微小 RNA 作为潜在的癌症治疗方法。
MicroRNAs as potential cancer therapeutics.
机构信息
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.
出版信息
Oncogene. 2008 Dec;27 Suppl 2(Suppl 2):S52-7. doi: 10.1038/onc.2009.353.
Abstract
MicroRNAs (miRNAs) have been shown to have an important role in various cellular processes, such as apoptosis, differentiation and development. Recent studies have shown that miRNAs are mis-expressed in human cancers where they can exert their effect as oncogenes or tumor suppressors. Here, we review the potential for using miRNAs as biomarkers for diagnosis, prognosis and cancer therapies.
摘要
微小 RNA（miRNAs）在各种细胞过程中具有重要作用，例如细胞凋亡、分化和发育。最近的研究表明，miRNAs 在人类癌症中表达异常，它们可以作为癌基因或肿瘤抑制因子发挥作用。在这里，我们综述了将 miRNAs 作为诊断、预后和癌症治疗的生物标志物的潜力。
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