视网膜静脉分支阻塞性黄斑水肿玻璃体切除术后黄斑区微循环的变化。
Macular microcirculation before and after vitrectomy for macular edema with branch retinal vein occlusion.
机构信息
Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, 477-96, Owada-shinden, Yachiyo, Chiba, 276-8524, Japan.
出版信息
Graefes Arch Clin Exp Ophthalmol. 2010 Mar;248(3):443-5. doi: 10.1007/s00417-009-1250-z. Epub 2009 Dec 3.
BACKGROUND
The changes of perifoveal capillary blood flow velocity (BFV), visual acuity, and retinal thickness after pars plana vitrectomy (PPV) have been unclear in patients with branch retinal vein occlusion (BRVO) and macular edema.
METHODS
In a prospective study, PPV was performed on six eyes of six consecutive BRVO patients with macular edema (two women and four men; mean age: 66.3 +/- 5.0 years). Patients were examined preoperatively and 6 months postoperatively. BFV was measured by fluorescein angiography using a scanning laser ophthalmoscope and the tracing method. Macular thickness was examined by optical coherence tomography. Visual acuity was measured preoperatively and postoperatively, and data were converted to the logarithm of the minimum angle of resolution (logMAR).
RESULTS
In all six treated eyes, the macular thickness decreased significantly compared with before PPV (464 +/- 98 microm versus 224 +/- 55 microm, P = 0.0082), mean BFV increased significantly compared with before PPV (1.14 +/- 0.14 mm/sec versus 1.46 +/- 0.21 mm/sec, P = 0.0013), and mean logMAR decreased significantly compared with before PPV (0.57 +/- 0.34 versus 0.17 +/- 0.21, P = 0.0036).
CONCLUSIONS
PPV may improve perifoveal microcirculation and the visual prognosis in BRVO patients with macular edema.
背景
在伴有黄斑水肿的视网膜分支静脉阻塞（BRVO）患者中，玻璃体内切除术（PPV）后周边黄斑毛细血管血流速度（BFV）、视力和视网膜厚度的变化尚不清楚。
方法
前瞻性研究纳入 6 例 BRVO 伴黄斑水肿的患者（6 只眼，2 名女性，4 名男性；平均年龄 66.3 ± 5.0 岁），行 PPV。患者术前和术后 6 个月接受检查。使用扫描激光检眼镜和追踪法通过荧光素血管造影测量 BFV。通过光学相干断层扫描检查黄斑厚度。术前和术后测量视力，并将数据转换为最小分辨角对数（logMAR）。
结果
所有 6 只治疗眼的黄斑厚度与术前相比显著降低（464 ± 98 µm 比 224 ± 55 µm，P = 0.0082），平均 BFV 与术前相比显著增加（1.14 ± 0.14 mm/sec 比 1.46 ± 0.21 mm/sec，P = 0.0013），平均 logMAR 与术前相比显著降低（0.57 ± 0.34 比 0.17 ± 0.21，P = 0.0036）。
结论
PPV 可能改善伴有黄斑水肿的 BRVO 患者周边微循环和视力预后。
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