Seppälä T, Partinen M, Penttilä A, Aspholm R, Tiainen E, Kaukianen A
Department of Neurology, University of Helsinki, Finland.
J Intern Med. 1991 Jan;229(1):23-8. doi: 10.1111/j.1365-2796.1991.tb00301.x.
An autopsy was performed in 460 consecutive cases of sudden death among 35- to 76-year-old men. The closest cohabiting individual known to each decreased subject was interviewed. Snoring history was obtained in 321 of the 371 interviews. In 86 cases there was a history of 'habitual' (almost always or always) snoring, and 88 men snored 'often'. The mean age of subjects was 55.4 years. The mean body mass index (BMI) was 26.3 kg m-2. Among the obese snorers (n = 82), apnoeas had been observed 'occasionally', 'often', or 'habitually' in 49 cases. Death was classified as cardiovascular in 186 (40.4%) cases. Cardiovascular cause of death was more common among those who snored habitually or often than among those who snored occasionally or never (P less than 0.05). 'Habitual' snorers died more often while sleeping (P less than 0.05). Habitual snoring was found to be a risk factor for morning death (P less than 0.01). The possibility of obstructive sleep apnoea as a cause of sudden death should at least be considered if the decreased is known to have been a habitual snorer.
对35至76岁男性连续460例猝死病例进行了尸检。对每位死者已知的关系最密切的同居者进行了访谈。在371次访谈中,有321次获得了打鼾史。其中86例有“习惯性”(几乎总是或总是)打鼾史,88名男性“经常”打鼾。受试者的平均年龄为55.4岁。平均体重指数(BMI)为26.3kg/m²。在肥胖打鼾者(n = 82)中,49例曾“偶尔”“经常”或“习惯性”观察到呼吸暂停。186例(40.4%)死亡被归类为心血管疾病。习惯性或经常打鼾者的心血管疾病死亡原因比偶尔或从不打鼾者更为常见(P<0.05)。“习惯性”打鼾者在睡眠中死亡的情况更多(P<0.05)。习惯性打鼾被发现是早晨死亡的一个危险因素(P<0.01)。如果已知死者是习惯性打鼾者,则至少应考虑阻塞性睡眠呼吸暂停作为猝死原因的可能性。