Finn C A, Pope M D, Milligan S R
Department of Veterinary Preclinical Sciences, University of Liverpool, UK.
J Reprod Fertil. 1989 Jul;86(2):619-26. doi: 10.1530/jrf.0.0860619.
Oil, carrageenan or saline were injected into the uteri of ovariectomized mice treated with hormones on schedules which would sensitize, partly sensitize or not sensitize the uterus to an intraluminal decidual stimulus. The uterine epithelium was examined histologically at various times over the succeeding 5 h. Saline did not produce any morphological change whereas almost immediately after the injection of oil or carrageenan epithelial cell death was apparent in the uterus, regardless of hormone treatment. Within 45 min the dead cells had been removed and the epithelium was re-established. Oil droplets were still present in the uterus after 5 h and these were able to stimulate a decidual reaction in partly sensitized animals when oestrogen was administered 18-44 h after the oil instillation, well after the re-establishment of the epithelium. It is suggested that the early transient cell death in the uterine epithelium is not responsible for triggering the decidual reaction but that it is the contact of the oil droplet with an intact epithelium which triggers the response when the hormonal conditions so allow.
将油、角叉菜胶或生理盐水按照能使子宫对腔内蜕膜刺激敏感、部分敏感或不敏感的时间表，注射到用激素处理过的去卵巢小鼠的子宫中。在随后的5小时内，在不同时间对子宫上皮进行组织学检查。生理盐水未产生任何形态学变化，而注射油或角叉菜胶后，无论激素处理如何，子宫内几乎立即出现上皮细胞死亡。45分钟内，死亡细胞被清除，上皮重新形成。5小时后，油滴仍存在于子宫中，当在油滴注入后18 - 44小时（上皮重新形成很久之后）给予雌激素时，这些油滴能够在部分敏感的动物中刺激蜕膜反应。有人认为，子宫上皮早期短暂的细胞死亡并非引发蜕膜反应的原因，而是当激素条件允许时，油滴与完整上皮的接触引发了这种反应。
