Center for Magnetic Resonance Research, University of Illinois at Chicago, Chicago, IL 60612, USA.
Neuroimaging Clin N Am. 2009 Nov;19(4):615-24. doi: 10.1016/j.nic.2009.09.001.
Treatment of high-grade primary brain tumors is based on experience from multicenter trials. However, the prognosis has changed little in 3 decades. This suggests that there is a fundamental oversight in treatment. This article provides an imaging perspective of how regional responses of primary brain tumors may be examined to guide a flexible treatment plan. Sodium imaging provides a measurement of cell density that can be used to measure regional cell kill. Such a bioscales of regionally and temporally sensitive biologic-based parameters may be helpful to guide tumor treatment. These suggestions are speculative and still being examined, but are presented to challenge the medical community to be receptive to changes in the standard of care when that standard continues to fail.
高级别原发性脑肿瘤的治疗基于多中心试验的经验。然而，30 年来，预后几乎没有变化。这表明在治疗中有一个根本的疏忽。本文从影像学的角度探讨如何检查原发性脑肿瘤的区域性反应，以指导灵活的治疗计划。钠成像提供了细胞密度的测量，可以用来测量区域性细胞杀伤。这样一种基于生物的区域性和时间敏感的生物尺度参数可能有助于指导肿瘤治疗。这些建议是推测性的，仍在研究中，但提出这些建议是为了挑战医学界，当现有的治疗标准继续失败时，要接受治疗标准的改变。
