定量钠磁共振成像和钠生物标测在脑肿瘤管理中的应用。
Quantitative sodium MR imaging and sodium bioscales for the management of brain tumors.
机构信息
Center for Magnetic Resonance Research, University of Illinois at Chicago, Chicago, IL 60612, USA.
出版信息
Neuroimaging Clin N Am. 2009 Nov;19(4):615-24. doi: 10.1016/j.nic.2009.09.001.
Abstract
Treatment of high-grade primary brain tumors is based on experience from multicenter trials. However, the prognosis has changed little in 3 decades. This suggests that there is a fundamental oversight in treatment. This article provides an imaging perspective of how regional responses of primary brain tumors may be examined to guide a flexible treatment plan. Sodium imaging provides a measurement of cell density that can be used to measure regional cell kill. Such a bioscales of regionally and temporally sensitive biologic-based parameters may be helpful to guide tumor treatment. These suggestions are speculative and still being examined, but are presented to challenge the medical community to be receptive to changes in the standard of care when that standard continues to fail.
摘要
高级别原发性脑肿瘤的治疗基于多中心试验的经验。然而，30 年来，预后几乎没有变化。这表明在治疗中有一个根本的疏忽。本文从影像学的角度探讨如何检查原发性脑肿瘤的区域性反应，以指导灵活的治疗计划。钠成像提供了细胞密度的测量，可以用来测量区域性细胞杀伤。这样一种基于生物的区域性和时间敏感的生物尺度参数可能有助于指导肿瘤治疗。这些建议是推测性的，仍在研究中，但提出这些建议是为了挑战医学界，当现有的治疗标准继续失败时，要接受治疗标准的改变。
相似文献
1
Quantitative sodium MR imaging and sodium bioscales for the management of brain tumors.定量钠磁共振成像和钠生物标测在脑肿瘤管理中的应用。
Neuroimaging Clin N Am. 2009 Nov;19(4):615-24. doi: 10.1016/j.nic.2009.09.001.
2
Design of cosine modulated very selective suppression pulses for MR spectroscopic imaging at 3T.用于3T磁共振波谱成像的余弦调制超选择性抑制脉冲设计
Magn Reson Med. 2009 Mar;61(3):533-40. doi: 10.1002/mrm.21842.
3
Partially parallel MR spectroscopic imaging of gliomas at 3T.3T下胶质瘤的部分并行磁共振波谱成像
Conf Proc IEEE Eng Med Biol Soc. 2006;2006:493-6. doi: 10.1109/IEMBS.2006.259793.
4
Low-grade glioma: correlation of short echo time 1H-MR spectroscopy with 23Na MR imaging.低级别胶质瘤：短回波时间1H磁共振波谱与23Na磁共振成像的相关性
AJNR Am J Neuroradiol. 2008 Mar;29(3):464-70. doi: 10.3174/ajnr.A0854. Epub 2008 Jan 31.
5
Imaging of brain tumors: MR spectroscopy and metabolic imaging.脑肿瘤影像学：磁共振波谱和代谢成像。
Neuroimaging Clin N Am. 2010 Aug;20(3):293-310. doi: 10.1016/j.nic.2010.04.003.
6
Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma.促纤维增生性星形细胞瘤的灌注磁共振成像和磁共振波谱分析。
J Neuroradiol. 2012 Jul;39(3):190-4. doi: 10.1016/j.neurad.2011.09.003. Epub 2011 Nov 23.
7
Observation of anomalous diffusion in excised tissue by characterizing the diffusion-time dependence of the MR signal.通过表征磁共振信号的扩散时间依赖性来观察切除组织中的异常扩散。
J Magn Reson. 2006 Dec;183(2):315-23. doi: 10.1016/j.jmr.2006.08.009. Epub 2006 Sep 8.
8
Brain tumors: a multimodality approach with diffusion-weighted imaging, diffusion tensor imaging, magnetic resonance spectroscopy, dynamic susceptibility contrast and dynamic contrast-enhanced magnetic resonance imaging.脑肿瘤：采用扩散加权成像、扩散张量成像、磁共振波谱、动态磁敏感对比和动态对比增强磁共振成像的多模态方法
Magn Reson Imaging Clin N Am. 2013 May;21(2):199-239. doi: 10.1016/j.mric.2013.02.003.
9
Feasibility of 39-potassium MR imaging of a human brain at 9.4 Tesla.9.4特斯拉下人体大脑39-钾磁共振成像的可行性
Magn Reson Med. 2014 May;71(5):1819-25. doi: 10.1002/mrm.24821. Epub 2013 Jun 24.
10
Fast nosologic imaging of the brain.脑部快速疾病分类成像
J Magn Reson. 2007 Feb;184(2):292-301. doi: 10.1016/j.jmr.2006.10.017. Epub 2006 Nov 22.
引用本文的文献
1
Super-resolution sodium MRI of human gliomas at 3T using physics-based generative artificial intelligence.使用基于物理的生成式人工智能在3T条件下对人脑胶质瘤进行超分辨率钠磁共振成像。
J Neurooncol. 2025 Jun 3. doi: 10.1007/s11060-025-05094-x.
2
23Na-MRI for Breast Cancer Diagnosis and Treatment Monitoring: A Scoping Review.用于乳腺癌诊断和治疗监测的23钠磁共振成像：一项范围综述
Bioengineering (Basel). 2025 Feb 6;12(2):158. doi: 10.3390/bioengineering12020158.
3
Hardware and Software Setup for Quantitative Na Magnetic Resonance Imaging at 3T: A Phantom Study.硬件和软件设置用于 3T 下定量 Na 磁共振成像：一项体模研究。
Sensors (Basel). 2024 Apr 24;24(9):2716. doi: 10.3390/s24092716.
4
Assessment of sodium (Na) brain MRI at 3T - preliminary results.3T 下钠（Na）脑磁共振成像评估——初步结果
Pol J Radiol. 2023 Jul 28;88:e343-e348. doi: 10.5114/pjr.2023.130252. eCollection 2023.
5
Hybrid PET/MRI in Cerebral Glioma: Current Status and Perspectives.脑胶质瘤中的PET/MRI融合成像：现状与展望
Cancers (Basel). 2023 Jul 12;15(14):3577. doi: 10.3390/cancers15143577.
6
Increased brain tissue sodium concentration in Friedreich ataxia: A multimodal MR imaging study.弗里德里希共济失调患者脑组织钠离子浓度升高：一项多模态磁共振成像研究。
Neuroimage Clin. 2022;34:103025. doi: 10.1016/j.nicl.2022.103025. Epub 2022 Apr 26.
7
Sodium MRI at 7T for Early Response Evaluation of Intracranial Tumors following Stereotactic Radiotherapy Using the CyberKnife.7T 磁共振钠成像用于评估 CyberKnife 立体定向放疗后颅内肿瘤的早期反应。
AJNR Am J Neuroradiol. 2022 Feb;43(2):181-187. doi: 10.3174/ajnr.A7404.
8
The Role of Molecular Imaging as a Marker of Remyelination and Repair in Multiple Sclerosis.分子影像学在多发性硬化症中的髓鞘修复和再生标志物中的作用。
Int J Mol Sci. 2021 Dec 31;23(1):474. doi: 10.3390/ijms23010474.
9
Assessment of Sodium MRI at 7 Tesla as Predictor of Therapy Response and Survival in Glioblastoma Patients.7特斯拉钠磁共振成像评估胶质母细胞瘤患者治疗反应及生存情况的预测价值
Front Neurosci. 2021 Dec 1;15:782516. doi: 10.3389/fnins.2021.782516. eCollection 2021.
10
Sodium MR Neuroimaging.磁共振神经成像中的钠成像。
AJNR Am J Neuroradiol. 2021 Nov;42(11):1920-1926. doi: 10.3174/ajnr.A7261. Epub 2021 Aug 26.
本文引用的文献
1
Comparison of (18)F-FET and (18)F-FDG PET in brain tumors.(18)F-FET与(18)F-FDG PET在脑肿瘤中的比较。
Nucl Med Biol. 2009 Oct;36(7):779-87. doi: 10.1016/j.nucmedbio.2009.05.005. Epub 2009 Jul 29.
2
Pseudoprogression and MGMT status in glioblastoma patients: implications in clinical practice.胶质母细胞瘤患者的假性进展与MGMT状态：对临床实践的影响
Anticancer Res. 2009 Jul;29(7):2607-10.
3
Fast quantitative mapping of absolute water content with full brain coverage.全脑覆盖的绝对含水量快速定量映射。
Neuroimage. 2008 Sep 1;42(3):1094-109. doi: 10.1016/j.neuroimage.2008.03.060. Epub 2008 Apr 11.
4
Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402.单纯性和混合性间变性少突胶质细胞瘤化疗联合放疗与单纯放疗的III期试验：肿瘤放射治疗协作组9402试验
J Clin Oncol. 2006 Jun 20;24(18):2707-14. doi: 10.1200/JCO.2005.04.3414.
5
Anaplastic oligodendroglial tumors: a tale of two trials.间变性少突胶质细胞瘤：两项试验的故事
J Clin Oncol. 2006 Jun 20;24(18):2689-90. doi: 10.1200/JCO.2006.05.8594.
6
Design and analysis of a practical 3D cones trajectory.一种实用的三维锥体轨迹的设计与分析
Magn Reson Med. 2006 Mar;55(3):575-82. doi: 10.1002/mrm.20796.
7
Sodium MR imaging of acute and subacute stroke for assessment of tissue viability.用于评估组织活力的急性和亚急性卒中的钠磁共振成像。
Neuroimaging Clin N Am. 2005 Aug;15(3):639-53, xi-xii. doi: 10.1016/j.nic.2005.08.003.
8
Rapid in vivo Taxotere quantitative chemosensitivity response by 4.23 Tesla sodium MRI and histo-immunostaining features in N-Methyl-N-Nitrosourea induced breast tumors in rats.通过4.23特斯拉钠磁共振成像及组织免疫染色特征对大鼠N-甲基-N-亚硝基脲诱导的乳腺肿瘤进行体内多西他赛快速定量化学敏感性反应研究
Cancer Cell Int. 2005 Aug 3;5:26. doi: 10.1186/1475-2867-5-26.
9
Rapid in vivo monitoring of chemotherapeutic response using weighted sodium magnetic resonance imaging.使用加权钠磁共振成像对化疗反应进行快速体内监测。
Clin Cancer Res. 2000 Jun;6(6):2146-56.
10
Comprehensive MR imaging protocol for stroke management: tissue sodium concentration as a measure of tissue viability in nonhuman primate studies and in clinical studies.
Radiology. 1999 Oct;213(1):156-66. doi: 10.1148/radiology.213.1.r99se15156.
Zotero 插件