Faculty of Agriculture and Life Science, Hirosaki University, 3 Bunkyo-Cho, Hirosaki, Aomori 036-8561, Japan.
Bioorg Med Chem Lett. 2010 Jan 15;20(2):709-12. doi: 10.1016/j.bmcl.2009.11.063. Epub 2009 Dec 3.
Novel fusapyrone analogs, deoxyneofusapyrone and 7-desmethyldeoxyneofusapyrone were isolated from a pathogenic fungus, Verticillium dahliae, which causes Verticillium wilt disease in Helianthus annuus. Spectral analyses revealed that these are 2-pyrone type analogs of deoxyfusapyrone and its 7-desmethyl derivative, respectively. Biological assay disclosed that 10microg of deoxyneofusapyrone inhibited the growth of MRSA clinical isolate 87-7927.
新型 Fusapyrone 类似物，脱氧 Neofusapyrone 和 7-去甲脱氧 Neofusapyrone 从致病真菌 Verticillium dahliae 中分离出来，该真菌可引起向日葵的黄萎病。光谱分析表明，它们分别是脱氧 Fusapyrone 和其 7-去甲基衍生物的 2-吡喃酮类类似物。生物测定表明，脱氧 Neofusapyrone 的 10μg 抑制了 MRSA 临床分离株 87-7927 的生长。
