镰孢吡喃酮和脱氧镰孢吡喃酮，两种来自半裸镰刀菌的抗真菌α-吡喃酮。

Fusapyrone and deoxyfusapyrone, two antifungal alpha-pyrones from Fusarium semitectum.

作者信息

Evidente A, Conti L, Altomare C, Bottalico A, Sindona G, Segre A L, Logrieco A

机构信息

Dipartimento di Scienze Chimico-Agrarie, Università di Napoli Federico II, Portici, Italy.

出版信息

Nat Toxins. 1994;2(1):4-13. doi: 10.1002/nt.2620020103.

DOI:10.1002/nt.2620020103

PMID:8032694

Abstract

A strain of Fusarium semitectum Berk. & Rav. from maize stalk rot in southern Italy produced bioactive metabolites when cultured on autoclaved rice kernels at room temperature for 4 weeks. The organic extracts of fungal culture showed a strong antibiotic activity towards Geotrichum candidum in disk diffusion assays, but they were not toxic to Artemia salina larvae. Two antifungal metabolites were isolated and characterized by chemical and spectroscopic methods as two 3-substituted-4-hydroxy-6-alkyl-2-pyrones, in particular, the 3-(4-deoxy-beta-xylo-hexopyranosyl)-4-hydroxy-6-[2-hydroxy-7-hydroxymeth yl- 1,1,5,9,11-pentamethyl-3,5,8-heptadecatrienyl]-2H-pyran-2-one and its 6-[2-hydroxy-1,1,5,7,9,11-hexamethyl] analog, which were named fusapyrone and deoxyfusapyrone, respectively.

摘要

从意大利南部玉米茎腐病中分离出的一株半裸镰刀菌（Fusarium semitectum Berk. & Rav.），在室温下于高压灭菌的稻粒上培养4周后产生了生物活性代谢产物。在纸片扩散试验中，真菌培养物的有机提取物对白色地霉（Geotrichum candidum）显示出很强的抗菌活性，但对卤虫（Artemia salina）幼虫无毒。通过化学和光谱方法分离并鉴定出两种抗真菌代谢产物为两种3-取代-4-羟基-6-烷基-2-吡喃酮，具体为3-(4-脱氧-β-D-吡喃己糖基)-4-羟基-6-[2-羟基-7-羟甲基-1,1,5,9,11-五甲基-3,5,8-十七碳三烯基]-2H-吡喃-2-酮及其6-[2-羟基-1,1,5,7,9,11-六甲基]类似物，它们分别被命名为镰刀菌吡喃酮和脱氧镰刀菌吡喃酮。