来自巴西橡胶树叶内生真菌简单节丛孢PSU-H41的缩酚酸酮类化合物和一种α-吡喃酮衍生物[校正后] 。

Depsidones and an α-pyrone derivative from Simplicillium sp. PSU-H41, an endophytic fungus from Hevea brasiliensis leaf [corrected].

作者信息

Saetang Praphatsorn, Rukachaisirikul Vatcharin, Phongpaichit Souwalak, Preedanon Sita, Sakayaroj Jariya, Borwornpinyo Suparerk, Seemakhan Sawinee, Muanprasat Chatchai

机构信息

Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.

出版信息

Phytochemistry. 2017 Nov;143:115-123. doi: 10.1016/j.phytochem.2017.08.002. Epub 2017 Aug 10.

DOI:10.1016/j.phytochem.2017.08.002

PMID:28803995

Abstract

Nine previously undescribed depsidones (simplicildones A-I) and one previously undescribed α-pyrone (simplicilopyrone) were isolated from the endophytic fungus Simplicillium sp. PSU-H41 along with 11 known compounds. Their structures were established by extensive spectroscopic analysis. Simplicildone A and known botryorhodine C displayed weak antibacterial against Staphylococcus aureus with equal MIC values of 32 μg/mL. Additionally, botryorhodine C was active against methicillin-resistant S. aureus with the same MIC value. Simplicildone C exhibited weak antifungal activity against Cryptococcus neoformans with an MIC value of 32 μg/mL. In addition, simplicildones A and C and botryorhodine C were noncytotoxic against noncancerous Vero cells.

摘要

从内生真菌简梗孢属PSU - H41中分离出9种此前未描述过的缩酚酸酮（简梗孢缩酚酸酮A - I）和1种此前未描述过的α - 吡喃酮（简梗孢吡喃酮），同时还分离出11种已知化合物。通过广泛的光谱分析确定了它们的结构。简梗孢缩酚酸酮A和已知的葡萄色菌素C对金黄色葡萄球菌显示出微弱的抗菌活性，最低抑菌浓度（MIC）值均为32μg/mL。此外，葡萄色菌素C对耐甲氧西林金黄色葡萄球菌具有相同MIC值的活性。简梗孢缩酚酸酮C对新型隐球菌表现出微弱的抗真菌活性，MIC值为32μg/mL。此外，简梗孢缩酚酸酮A和C以及葡萄色菌素C对非癌性Vero细胞无细胞毒性。