Rolston John D, Gross Robert E, Potter Steve M
Department of Neurological Surgery, Emory University School of Medicine, Atlanta, GA 30322 USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:1604-7. doi: 10.1109/IEMBS.2009.5333230.
Referencing is frequently used to remove common-mode signals from multielectrode data, in both freely moving animals and in vitro preparations. For action potential (AP) detection, referencing by subtracting the common average signal has been shown to increase AP signal-to-noise ratio (SNR). This method fails, however, when large transients occur on individual electrodes, as occurs during electrical stimulation or with large APs during spontaneous recordings. To deal with these cases, we propose using the common median as a reference. The common median has an improved SNR for AP detection (leading to more isolated single units and more detected APs per unit) and, unlike common average referencing, does not generate spurious APs when processing large single-electrode transients.
在自由活动的动物和体外制备实验中，参考技术经常用于去除多电极数据中的共模信号。对于动作电位（AP）检测，通过减去公共平均信号进行参考已被证明可以提高AP的信噪比（SNR）。然而，当单个电极上出现大的瞬变时，这种方法就会失效，比如在电刺激期间或自发记录时出现大的AP时。为了处理这些情况，我们建议使用公共中位数作为参考。公共中位数在AP检测中具有更高的信噪比（能导致更多孤立的单个单元以及每个单元检测到更多的AP），并且与公共平均参考不同，在处理大的单电极瞬变时不会产生虚假的AP。
