mRNA 定位在动物发育中的原理和作用。
Principles and roles of mRNA localization in animal development.
机构信息
Institute of Biology Valrose, University of Nice-Sophia Antipolis/UMR7277 CNRS/UMR1091 INSERM, Parc Valrose, 06108 Nice Cedex 2, France.
出版信息
Development. 2012 Sep;139(18):3263-76. doi: 10.1242/dev.078626.
Abstract
Intracellular targeting of mRNAs has long been recognized as a means to produce proteins locally, but has only recently emerged as a prevalent mechanism used by a wide variety of polarized cell types. Localization of mRNA molecules within the cytoplasm provides a basis for cell polarization, thus underlying developmental processes such as asymmetric cell division, cell migration, neuronal maturation and embryonic patterning. In this review, we describe and discuss recent advances in our understanding of both the regulation and functions of RNA localization during animal development.
摘要
长期以来，人们一直认为将 mRNAs 靶向到细胞内是一种在局部产生蛋白质的方法，但直到最近，它才作为一种广泛存在的机制被各种极化细胞类型所采用。mRNA 分子在细胞质内的定位为细胞极化提供了基础，从而为不对称细胞分裂、细胞迁移、神经元成熟和胚胎模式形成等发育过程提供了基础。在这篇综述中，我们描述并讨论了在动物发育过程中对 RNA 定位的调控和功能的理解的最新进展。
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2
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Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4645-50. doi: 10.1073/pnas.1111226109. Epub 2012 Mar 5.
3
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4
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