脂滴在膜间脂质运输中的作用。
A role for lipid droplets in inter-membrane lipid traffic.
作者信息
Zehmer John K, Huang Youguo, Peng Gong, Pu Jing, Anderson Richard G W, Liu Pingsheng
机构信息
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
出版信息
Proteomics. 2009 Feb;9(4):914-21. doi: 10.1002/pmic.200800584.
Abstract
All cells have the capacity to accumulate neutral lipids and package them into lipid droplets. Recent proteomic analyses indicate that lipid droplets are not simple lipid storage depots, but rather complex organelles that have multiple cellular functions. One of these proposed functions is to distribute neutral lipids as well as phospholipids to various membrane-bound organelles within the cell. Here, we summarize the lipid droplet-associated membrane-trafficking proteins and review the evidence that lipid droplets interact with endoplasmic reticulum, endosomes, peroxisomes, and mitochondria. Based on this evidence, we present a model for how lipid droplets can distribute lipids to specific membrane compartments.
摘要
所有细胞都有积累中性脂质并将其包装成脂滴的能力。最近的蛋白质组学分析表明，脂滴并非简单的脂质储存库，而是具有多种细胞功能的复杂细胞器。其中一个推测的功能是将中性脂质以及磷脂分配到细胞内各种膜结合细胞器中。在此，我们总结了与脂滴相关的膜运输蛋白，并综述了脂滴与内质网、内体、过氧化物酶体和线粒体相互作用的证据。基于这些证据，我们提出了一个关于脂滴如何将脂质分配到特定膜区室的模型。
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