左心室解旋随增龄的改变。

Alterations in left ventricular untwisting with ageing.

机构信息

Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, The Netherlands.

出版信息

Circ J. 2010 Jan;74(1):101-8. doi: 10.1253/circj.cj-09-0436. Epub 2009 Dec 7.

DOI:10.1253/circj.cj-09-0436

PMID:19966501

Abstract

BACKGROUND

In order to gain further insight into age-associated changes of left ventricular (LV) diastolic function, the purpose of the current study was to investigate alterations in LV untwisting with ageing.

METHODS AND RESULTS

The study comprised 75 healthy volunteers, classified into 3 groups: age 16-35 (n=25), 36-55 (n=25) and 56-75 (n=25) years. LV untwisting (as a percentage of peak systolic twist) at 5%, 10%, 15% and 50% of diastole, peak diastolic untwisting velocity, time-to-peak diastolic untwisting velocity and untwisting rate (mean untwisting velocity during the time interval from peak systolic twist to mitral valve opening) were assessed using speckle-tracking echocardiography. Untwisting at 5%, 10%, 15% and 50% of diastole decreased with ageing. Although the peak diastolic untwisting velocity and untwisting rate were not significantly different between the age groups, when normalized for LV peak systolic twist, these parameters decreased with advancing age (both P<0.01). Time-to-peak diastolic untwisting velocity increased with ageing (P<0.01).

CONCLUSIONS

Impairment of the relative peak diastolic untwisting velocity and untwisting rate, resulting in delayed LV untwisting, may help to explain diastolic dysfunction in the elderly. (Circ J 2010; 74: 101 - 108).

摘要

背景

为了深入了解与年龄相关的左心室（LV）舒张功能变化，本研究旨在探讨LV 解旋随年龄的变化。

方法和结果

该研究纳入了 75 名健康志愿者，分为 3 组：年龄 16-35 岁（n=25）、36-55 岁（n=25）和 56-75 岁（n=25）岁。使用斑点追踪超声心动图评估 LV 解旋（以收缩期峰值扭转的百分比表示）在舒张期的 5%、10%、15%和 50%、峰值舒张解旋速度、达峰舒张解旋速度和解旋率（从收缩期峰值扭转到二尖瓣开放的时间间隔内的平均解旋速度）。随着年龄的增长，舒张期的解旋在 5%、10%、15%和 50%处逐渐减少。尽管各组之间的峰值舒张解旋速度和解旋率无显著差异，但当按 LV 收缩期峰值扭转进行归一化时，这些参数随年龄的增长而降低（均 P<0.01）。达峰舒张解旋速度随年龄增长而增加（P<0.01）。