褐藻胶低聚糖对镉损伤蚕豆根尖细胞的缓解作用。
Alleviation effect of alginate-derived oligosaccharides on Vicia faba root tip cells damaged by cadmium.
机构信息
College of Chemistry and Life Science, Shenyang Normal University, 253 Huanghe Street, 110034 Shenyang, China.
出版信息
Bull Environ Contam Toxicol. 2010 Feb;84(2):161-4. doi: 10.1007/s00128-009-9914-2. Epub 2009 Dec 6.
Cadmium has been shown to prevent Vicia faba growth by inhibiting cell mitosis. In this study we investigated the role of Alginate-derived Oligosaccharides (ADO) in alleviating Vicia faba root tip cells damaged by 6 and 8 mg L(-1) CdCl2. Micronucleus assay and chromosomal aberration assay were used to determine mitotic index, micronucleus frequency and chromosomal aberration frequency. The results showed that micronucleus frequency of Vicia faba root tip cells was inhibited under all the ADO concentrations. Especially, the inhibition ratio of 0.125% ADO highly reached 66.11 and 67.17% in 6 and 8 mg L(-1) CdCl2, respectively. Furthermore, the mitotic index increased (p < 0.05) and chromosomal aberration frequency decreased (p < 0.05) under all the ADO concentrations. This indicated that ADO had a significant alleviation effect on Vicia faba root tip cells damaged by cadmium.
镉已被证明可通过抑制细胞有丝分裂来阻止蚕豆生长。在这项研究中，我们研究了 Alginate-derived Oligosaccharides (ADO) 在缓解 6 和 8 mg L(-1) CdCl2 损伤的蚕豆根尖细胞方面的作用。微核试验和染色体畸变试验用于确定有丝分裂指数、微核频率和染色体畸变频率。结果表明，在所有 ADO 浓度下，蚕豆根尖细胞的微核频率均受到抑制。特别是，0.125% ADO 的抑制率在 6 和 8 mg L(-1) CdCl2 中分别高达 66.11%和 67.17%。此外，在所有 ADO 浓度下，有丝分裂指数增加（p < 0.05），染色体畸变频率降低（p < 0.05）。这表明 ADO 对镉损伤的蚕豆根尖细胞具有显著的缓解作用。
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